2-((o-tolyl)(phenyl)phosphinothioyl)-2'-(diphenylphosphinothioyl)-1,10-binaphthyl | 1351866-66-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((o-tolyl)(phenyl)phosphinothioyl)-2'-(diphenylphosphinothioyl)-1,10-binaphthyl
• 英文别名: [1-[2-[Diphenyl(sulfido)phosphaniumyl]naphthalen-1-yl]naphthalen-2-yl]-(2-methylphenyl)-phenyl-sulfidophosphanium；[1-[2-[diphenyl(sulfido)phosphaniumyl]naphthalen-1-yl]naphthalen-2-yl]-(2-methylphenyl)-phenyl-sulfidophosphanium
• CAS: 1351866-66-4
• 化学式: C₄₅H₃₄P₂S₂
• 分子量: 700.844
• InChiKey: HZURUAFMCJOWAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.8
• 重原子数：
  49
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.02
• 拓扑面积：
  2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-1,1'-Bi-2-naphthol 在 吡啶 、 1,2-双(二苯基膦)乙烷氯化镍 、 苯硅烷 、 palladium diacetate 、 N,N-二异丙基乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 生成 2-((o-tolyl)(phenyl)phosphinothioyl)-2'-(diphenylphosphinothioyl)-1,10-binaphthyl
  参考文献：
  名称：

  Synthesis of P-stereogenic BINAP bissulfide analogues

  摘要：

  A synthetic route to BINAP disulfide analogues with chirality on one of the phosphorus atoms was developed. The synthesis of these ligands was achieved by step-wise palladium and nickel-catalysed coupling reactions of the precursor binaphthyl triflate with secondary phosphines and phosphine oxides, respectively. C2-Unsymmeric BINAP bissulfide analogues with the same aryl substituents were also synthesized for the sake of comparison. Preliminary studies of the reduction of these sulfides to the free phosphines are also described. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.09.007

文献信息

• Synthesis of P-stereogenic BINAP bissulfide analogues
  作者：Eoin Rafter、Jimmy Muldoon、Helge Müller Bunz、Declan G. Gilheany

  DOI：10.1016/j.tetasy.2011.09.007

  日期：2011.9

  A synthetic route to BINAP disulfide analogues with chirality on one of the phosphorus atoms was developed. The synthesis of these ligands was achieved by step-wise palladium and nickel-catalysed coupling reactions of the precursor binaphthyl triflate with secondary phosphines and phosphine oxides, respectively. C2-Unsymmeric BINAP bissulfide analogues with the same aryl substituents were also synthesized for the sake of comparison. Preliminary studies of the reduction of these sulfides to the free phosphines are also described. (C) 2011 Elsevier Ltd. All rights reserved.