2-(3-isopropylphenyl)benzyl alcohol | 1037085-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-isopropylphenyl)benzyl alcohol
• 英文别名: (3'-isopropylbiphenyl-2-yl)methanol；[2-(3-propan-2-ylphenyl)phenyl]methanol
• CAS: 1037085-36-1
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: XJMBSRBWESHTFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-isopropylphenyl)benzyl alcohol 在 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以63%的产率得到2-(3-异丙基苯基)苄基氯
  参考文献：
  名称：

  Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation

  摘要：

  A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes; were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance was also demonstrated. On the basis of Hammett and KIE studies, the present reaction is proposed to proceed via a base-assisted deprotonative metalation pathway.

  DOI：

  10.1021/ol901854f
• 作为产物：
  描述：

  2-溴苄醇 、 3-异丙基苯硼酸 在 racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl 、 potassium fluoride 、 palladium diacetate 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以93%的产率得到2-(3-isopropylphenyl)benzyl alcohol
  参考文献：
  名称：

  Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation

  摘要：

  A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes; were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance was also demonstrated. On the basis of Hammett and KIE studies, the present reaction is proposed to proceed via a base-assisted deprotonative metalation pathway.

  DOI：

  10.1021/ol901854f

文献信息

• Modulators of C3a receptor and methods of use thereof
  申请人：Biediger Ronald J.

  公开号：US20080188528A1

  公开（公告）日：2008-08-07

  Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.

  提供了一些化合物，它们是C3a受体活性的调节剂，包括含有这些化合物的组合物和使用这些化合物和组合物的方法。在某些实施例中，这些化合物是吡啶酮。在某些实施例中，提供了用于治疗或改善与C3a受体活性调节相关的疾病的方法。
• MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF
  申请人：ENCYSIVE PHARMACEUTICALS, INC.

  公开号：EP2125739A1

  公开（公告）日：2009-12-02
• [EN] MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DU RÉCEPTEUR DU C3A ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENCYSIVE PHARMACEUTICALS INC

  公开号：WO2008079371A1

  公开（公告）日：2008-07-03

  [EN] Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.
  [FR] L'invention propose des composés qui sont des modulateurs de l'activité du récepteur du C3a, des compositions contenant les composés et des procédés d'utilisation des composés et des compositions. Dans certains modes de réalisation, les composés sont des pyridones. Dans certains autres modes de réalisation, l'invention propose des procédés pour le traitement ou l'amélioration de maladies associées à la modulation de l'activité du récepteur du C3a.
• Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation
  作者：Seung Jun Hwang、Hyun Jin Kim、Sukbok Chang

  DOI：10.1021/ol901854f

  日期：2009.10.15

  A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes; were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance was also demonstrated. On the basis of Hammett and KIE studies, the present reaction is proposed to proceed via a base-assisted deprotonative metalation pathway.