叠氮-一聚乙二醇-4-碳酸硝基苯酯 | 1085377-75-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 叠氮-一聚乙二醇-4-碳酸硝基苯酯
• 英文名称: 2-azidoethyl (4-nitrophenyl) carbonate
• CAS: 1085377-75-8
• 化学式: C₉H₈N₄O₅
• 分子量: 252.186
• InChiKey: GKGHQKUUDBRYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  127.43
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  叠氮-一聚乙二醇-4-碳酸硝基苯酯 、 柔红霉素 盐酸盐 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以99%的产率得到2-azidoethyl(6-([(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl]oxy)-(2S,3S,4S,6R)-3-hydroxy-2-methyltetrahydro-2H-pyran-4-yl)carbamate
  参考文献：
  名称：

  N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products

  摘要：

  DOI：

  10.1007/s00044-022-02889-9
• 作为产物：
  描述：

  C₃₇H₃₇N₂O₈Pol 在 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 生成 叠氮-一聚乙二醇-4-碳酸硝基苯酯
  参考文献：
  名称：

  Protecting-Group-Based Colorimetric Monitoring of Fluorous-Phase and Solid-Phase Synthesis of Oligoglucosamines

  摘要：

  A new hydroxyl protecting group, nitrophthalimidobutyric (NPB) acid, has been synthesized in one solvent-free step for colorimetric monitoring of reaction cycles upon its facile removal with hydrazine acetate in the solid-phase and fluorous-phase syntheses of antigenic oligoglucosamines associated with infectious Staphylococcus aureus. The NPB group serves as a convenient hydroxyl protecting group that is stable to the basic conditions required for the synthesis of the common trichloroacetimidate protecting groups, the strongly acidic conditions used in glycosylation reactions, as well as conditions commonly used to remove silicon-based protecting groups.

  DOI：

  10.1021/ol802229b

文献信息

• Optical Cell Tagging for Spatially Resolved Single‐Cell RNA Sequencing
  作者：Qi Tang、Lu Liu、Yilan Guo、Xu Zhang、Shaoran Zhang、Yan Jia、Yifei Du、Bo Cheng、Li Yang、Yanyi Huang、Xing Chen

  DOI：10.1002/anie.202113929

  日期：2022.2.7

  OpTAG (optical cell tagging) is a novel chemical platform for attaching functional tags onto cell surfaces in a spatially resolved manner. In combination with cell sorting and single-cell RNA sequencing (scRNA-seq), OpTAG-seq enables spatially resolved scRNA-seq.

  OpTAG（光学细胞标记）是一种新型化学平台，用于以空间分辨的方式将功能性标记附加到细胞表面。结合细胞分选和单细胞 RNA 测序 (scRNA-seq)，OpTAG-seq 可实现空间分辨的 scRNA-seq。
• [EN] ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] CONJUGUÉS ANTICORPS-MÉDICAMENT DE COMPOSÉS ANTI-CANCÉREUX ET PROCÉDÉS D'UTILISATION
  申请人：[en]NOVARTIS AG

  公开号：WO2023225359A1

  公开（公告）日：2023-11-23

  Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed.