Eth-(E)-ylidene-((R)-2-methoxy-1-phenyl-ethyl)-amine | 91298-70-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Eth-(E)-ylidene-((R)-2-methoxy-1-phenyl-ethyl)-amine
• 英文别名: N-[(1R)-2-methoxy-1-phenylethyl]ethanimine
• CAS: 91298-70-3
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: RXPMZNXXXINJGZ-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Eth-(E)-ylidene-((R)-2-methoxy-1-phenyl-ethyl)-amine 在 六甲基磷酰三胺 、 正丁基锂 、 三氟化硼乙醚 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 (1S,1'R)-N-(2'-methoxy-1'-phenylethyl)-1-methylpropylamine
  参考文献：
  名称：

  Facile Asymmetric Synthesis of Aziridine Derivatives via the Diastereoselective Reaction of Chiral Imines with Dimethylsulfonium Methylide

  摘要：

  A simple method for the synthesis of chiral 2-substituted aziridine derivatives is described. The reaction pathway consists of the diastereoselective addition of dimethylsulfonium methylide to chiral imines derived from (R)-phenylglycinol and various aldehydes.

  DOI：

  10.3987/com-02-s(m)32
• 作为产物：
  描述：

  (R)-(-)-2-甲氧基-1-苯乙胺 、 乙醛 在 magnesium sulfate 作用下， 以 二氯甲烷 为溶剂， 生成 Eth-(E)-ylidene-((R)-2-methoxy-1-phenyl-ethyl)-amine
  参考文献：
  名称：

  Facile Asymmetric Synthesis of Aziridine Derivatives via the Diastereoselective Reaction of Chiral Imines with Dimethylsulfonium Methylide

  摘要：

  A simple method for the synthesis of chiral 2-substituted aziridine derivatives is described. The reaction pathway consists of the diastereoselective addition of dimethylsulfonium methylide to chiral imines derived from (R)-phenylglycinol and various aldehydes.

  DOI：

  10.3987/com-02-s(m)32

文献信息

• Facile Asymmetric Synthesis of Aziridine Derivatives via the Diastereoselective Reaction of Chiral Imines with Dimethylsulfonium Methylide
  作者：Kimio Higashiyama、Masataka Matsumura、Ayako Shiogama、Takayasu Yamauchi、Sigeru Ohmiya

  DOI：10.3987/com-02-s(m)32

  日期：——

  A simple method for the synthesis of chiral 2-substituted aziridine derivatives is described. The reaction pathway consists of the diastereoselective addition of dimethylsulfonium methylide to chiral imines derived from (R)-phenylglycinol and various aldehydes.