1-aza-8-methyl-8-hydroxy-11-oxo bicyclo (5.4.0) undecane | 116461-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-aza-8-methyl-8-hydroxy-11-oxo bicyclo (5.4.0) undecane
• CAS: 116461-05-3；116480-97-8
• 化学式: C₁₁H₁₉NO₂
• 分子量: 197.277
• InChiKey: WSTXEJFUKGVKCL-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  40.54
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  Benzyl 2-ethoxyazepane-1-carboxylate 在 palladium on activated charcoal 三氟甲磺酸三甲基硅酯 、 氢气 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 1-aza-8-methyl-8-hydroxy-11-oxo bicyclo (5.4.0) undecane
  参考文献：
  名称：

  Diastereoselection of the addition of silyloxyfurans to five-, six- and seven-membered N-acyliminium ions

  摘要：

  The addition of silyloxyfuran 1a to five-, six- and seven-membered N-acyliminium ions 2 afforded threo-3 as the major isomers (the structures of 3a, 3g and 3m were determined by X-ray analysis). The diastereoisomeric ratio increased with bulkier carbamate groups (Boc>Cbz>CO2Me) with the five- and seven-membered N-acyliminium ions more selective than the six-membered ones. However. erythro-4 isomers predominated when 5-methylsilyloxyfuran 1b was employed (the structures were determined by NOE studies on the corresponding bicyclic lactams 6a.b and 7a,b) and the formation or regioisomer 5 was observed for N-acyliminium ions with Boc (seven-membered series) and Cbz (six- and seven-membered series) groups. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01388-0

文献信息

• Azzouzi, Assia; Dufour, Monique; Gramain, Jean-Claude, Heterocycles, 1988, vol. 27, # 1, p. 133 - 148
  作者：Azzouzi, Assia、Dufour, Monique、Gramain, Jean-Claude、Remuson, Roland

  DOI：——

  日期：——