(E)-(S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-1-ol | 479495-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-1-ol
• 英文别名: (E,2S)-4-[3-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-methylbut-3-en-1-ol
• CAS: 479495-43-7
• 化学式: C₁₇H₂₈O₂Si
• 分子量: 292.494
• InChiKey: SISJBDADURGLRY-VNDWYCCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-(S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-1-ol 在 palladium on activated charcoal 氢气 作用下， 生成 (S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-butyraldehyde
  参考文献：
  名称：

  Progress towards the decalin portion of (+)-compactin

  摘要：

  A new approach to a chiral tetrahydronaphthalene precursor for the decalin portion of (+)-compactin is disclosed. The strategy utilises two key steps: a boron-catalysed diastereoselective annulation reaction to a key dioxaborin ester which was then transformed to a dioxaphosphinin-2-oxide for use in a diastereoselective S,,2 reaction affording the two substituents at C-1 and C-2 with the cis stereochemistry required in a (+)-compactin skeleton. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00570-0
• 作为产物：
  描述：

  间羟基苯甲醛 在 咪唑 、 正丁基锂 作用下， 生成 (E)-(S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-1-ol
  参考文献：
  名称：

  Progress towards the decalin portion of (+)-compactin

  摘要：

  A new approach to a chiral tetrahydronaphthalene precursor for the decalin portion of (+)-compactin is disclosed. The strategy utilises two key steps: a boron-catalysed diastereoselective annulation reaction to a key dioxaborin ester which was then transformed to a dioxaphosphinin-2-oxide for use in a diastereoselective S,,2 reaction affording the two substituents at C-1 and C-2 with the cis stereochemistry required in a (+)-compactin skeleton. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00570-0

文献信息

• Progress towards the decalin portion of (+)-compactin
  作者：Claude Dufresne、David Cretney、Cheuk K. Lau、Vincent Mascitti、Nancy Tsou

  DOI：10.1016/s0957-4166(02)00570-0

  日期：2002.9

  A new approach to a chiral tetrahydronaphthalene precursor for the decalin portion of (+)-compactin is disclosed. The strategy utilises two key steps: a boron-catalysed diastereoselective annulation reaction to a key dioxaborin ester which was then transformed to a dioxaphosphinin-2-oxide for use in a diastereoselective S,,2 reaction affording the two substituents at C-1 and C-2 with the cis stereochemistry required in a (+)-compactin skeleton. (C) 2002 Published by Elsevier Science Ltd.