Boc-dWF-OMe | 94778-77-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-dWF-OMe
• 英文别名: BocDTrp-PheOMe；methyl (2S)-2-[[(2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-3-phenylpropanoate
• CAS: 94778-77-5
• 化学式: C₂₆H₃₁N₃O₅
• 分子量: 465.549
• InChiKey: BHPJYWAIFNMZLM-YADHBBJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Boc-dWF-OMe 在 盐酸 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 苯甲醚 为溶剂， 生成 (S)-2-[(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester
  参考文献：
  名称：

  Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

  摘要：

  Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.084
• 作为产物：
  描述：

  L-苯丙氨酸甲酯 、 BOC-D-色氨酸 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-dWF-OMe
  参考文献：
  名称：

  Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

  摘要：

  Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.084

文献信息

• Palladium-Catalyzed C2-Regioselective Perfluoroalkylation of the Free (NH)-Heteroarenes
  作者：Hong Qin、Jie Zhang、Kai Qiao、Dong Zhang、Wei He、Chengkou Liu、Zheng Fang、Kai Guo

  DOI：10.1021/acs.joc.0c02782

  日期：2021.2.5

  A highly regioselective and atom-efficient strategy for the construction of fused free (NH) heteroarenes through a palladium-catalyzed perfluoroalkyl insertion reaction has been accomplished. This protocol employed multiple iodofluoroalkanes as practical and available perfluoroalkyl sources to provide an operationally simple and versatile route for the synthesis of perfluoroalkylated indoles. Moreover

  已经实现了通过钯催化的全氟烷基插入反应构建稠合的游离（NH）杂芳烃的高度区域选择性和原子效率高的策略。该方案采用多种碘氟烷烃作为实用和可用的全氟烷基来源，为合成全氟烷基化的吲哚提供了操作上简单而通用的途径。此外，没有指导小组协助的吲哚被用作底物，实现了吲哚的C（sp 2）–H位点选择性官能化，收率高达95％。此外，该协议还用于生物活性化合物（如植物生长素，色氨酸和褪黑激素类似物）的后期C2全氟烷基化。
• Hexapeptide amides
  申请人：Sterling Drug Inc.

  公开号：US04472305A1

  公开（公告）日：1984-09-18

  N-Terminal L-prolyl or D-prolyl hexapeptide amides useful as Substance P agonists and/or antagonists and as analgesics and/or antihypertensives and a process for preparing them are disclosed.

  本发明公开了N-端L-脯氨酰或D-脯氨酰六肽酰胺，其可用作物质P激动剂和/或拮抗剂，以及作为镇痛剂和/或降压剂，还公开了一种制备它们的方法。
• Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions
  作者：Lisa A. Liotta、Irene Medina、Jennifer L. Robinson、Chris L. Carroll、Po-Shen Pan、Ricardo Corral、Jennifer V.C. Johnston、Kristina M. Cook、Fiona A. Curtis、Gary J. Sharples、Shelli R. McAlpine

  DOI：10.1016/j.tetlet.2004.09.084

  日期：2004.11

  Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics. (C) 2004 Elsevier Ltd. All rights reserved.