(Z)-4-[(4-methoxyphenyl)methoxy]-3-methylbut-2-enal | 1013326-55-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-[(4-methoxyphenyl)methoxy]-3-methylbut-2-enal
• CAS: 1013326-55-0
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: XANAUQWZRFQJOU-XFFZJAGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-4-[(4-methoxyphenyl)methoxy]-3-methylbut-2-enal 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以43%的产率得到(E)-4-[(4-methoxyphenyl)methoxy]-3-methylbut-2-enal
  参考文献：
  名称：

  Alkyne-Enol Ether Cross-Metathesis in the Presence of CuSO₄: Direct Formation of 3-Substituted Crotonaldehydes in Aqueous Medium

  摘要：

  An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO4 and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making c, this approach safer, economic, and desiderable from an enviromental point of view.

  DOI：

  10.1021/jo900205x
• 作为产物：
  描述：

  (Z)-4-(4-methoxybenzyloxy)-3-methyl-but-2-en-1-ol 在 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 (Z)-4-[(4-methoxyphenyl)methoxy]-3-methylbut-2-enal
  参考文献：
  名称：

  Synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate

  摘要：

  The synthesis of enantiopure 2-C-methyl-D-erythritol-4-phosphate is disclosed. A 1,3-diol possessing a quaternary stereogenic centre, prepared stereo selectively from an acyclic tri-substituted alkene, has been utilized as a key intermediate. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.129

文献信息

• Stereoselective synthesis of chiral tertiary alcohol building blocks via neighbouring group participation from tri-substituted olefins
  作者：Sadagopan Raghavan、T. Sreekanth

  DOI：10.1016/j.tetlet.2007.12.046

  日期：2008.2

  A regio- and stereoselective preparation of chiral quaternary 1,2/1,3-diols from acyclic tri-substituted alkenes is disclosed. Optically active tertiary alcohols are the constituents of several bioactive natural products, pharmaceuticals and a general method for their preparation is desirable. A sulfinyl moiety has been utilized as an intramolecular nucleophile.

  公开了由无环三取代的烯烃的区域和立体选择性的手性季铵1,2 / 1,3-二醇的制备。旋光性叔醇是几种生物活性天然产物，药物的组成，因此需要一种通用的制备方法。亚磺酰基部分已被用作分子内亲核试剂。