Methyl 5-methoxy-2-(2-formyl-4-methoxyphenyl)-benzoate | 139962-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 5-methoxy-2-(2-formyl-4-methoxyphenyl)-benzoate
• 英文别名: methyl 2'-formyl-4,4'-dimethoxy-[1,1'-biphenyl]-2-carboxylate；Methyl 2-(2-formyl-4-methoxyphenyl)-5-methoxybenzoate
• CAS: 139962-98-4
• 化学式: C₁₇H₁₆O₅
• 分子量: 300.311
• InChiKey: VAKCVNZDPPHXFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 5-methoxy-2-(2-formyl-4-methoxyphenyl)-benzoate 在 水 、 lithium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以97%的产率得到2'-formyl-4,4'-dimethoxybiphenyl-2-carboxylic acid
  参考文献：
  名称：

  A Microwave-Assisted Diastereoselective Multicomponent Reaction To Access Dibenzo[c,e]azepinones: Synthesis and Biological Evaluation

  摘要：

  An unprecedented microwave-assisted multicomponent strategy has been elaborated for the fast, efficient, and diastereoselective generation of the dibenzo[c,e]azepinone scaffold. The generated compounds were evaluated for their bioactivity.

  DOI：

  10.1021/jo200251q
• 作为产物：
  描述：

  2-溴-5-甲氧基苯甲酸甲酯 、 4-甲氧基-2-甲酰基苯硼酸 在 四(三苯基膦)钯 、 碳酸氢钠 作用下， 生成 Methyl 5-methoxy-2-(2-formyl-4-methoxyphenyl)-benzoate
  参考文献：
  名称：

  Total synthesis of plagiochins C and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

  摘要：

  Plagiochins C (3) and D (4) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the aryl-aryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Ring C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.

  DOI：

  10.1016/s0040-4020(01)88193-x