1-(6-hydroxyhexyl-1-amino)anthraquinone | 122482-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-(6-hydroxyhexyl-1-amino)anthraquinone
• 英文别名: 1-(6-hydroxyhexylamino)anthraquinone；1-(6-Hydroxyhexylamino)anthracene-9,10-dione
• CAS: 122482-21-7
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: UGQCGKMMGYCNLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(6-hydroxyhexyl-1-amino)anthraquinone 在 吡啶 、 二溴亚砜 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-[6-(9,10-Dioxo-9,10-dihydro-anthracen-1-ylamino)-hexyl]-malonic acid di-tert-butyl ester
  参考文献：
  名称：

  Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs

  摘要：

  A series of complexes PtAm2L [where Am-2 = (NH3)(2), ethylenediamine(en), 1,2-diaminocyclohexane (DACH) or (NH3)(c-C6H11NH2) and where L is a bidentate 1,1-dicarboxylate ligand tethered to 1-aminoanthraquinone by various spacers] was prepared and screened in vitro against P388 leukemia cells. The free ligands displayed moderate activity and the corresponding platinum complexes were tenfold more active. The nature of the linker chain does not seem to affect the potency of the complexes. The potency depends on the nature of the inert amine ligand [NH3 > DACH > en]. The low aqueous solubility of these complexes prevented any in vivo studies and the preparation of water soluble analogs is currently under way.

  DOI：

  10.1016/s0223-5234(99)80068-3
• 作为产物：
  描述：

  6-氨基-1-己醇 、 1-氟蒽醌 在 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 25.0h， 生成 1-(6-hydroxyhexyl-1-amino)anthraquinone
  参考文献：
  名称：

  WO2007/147742

  摘要：

  公开号：

文献信息

• [EN] NANOPIGMENTS<br/>[FR] NANOPIGMENTS
  申请人：NVA IP HOLDINGS PTY LTD

  公开号：WO2010054441A1

  公开（公告）日：2010-05-20

  The present invention relates to a dye monomer of general formula (I): A - X - R - O - C(O) - O - CH2- C(H) = CH2,wherein A is a dye molecule and both X and R are optional linkers. The present invention also relates to particles comprising a copolymer of said dye monomer and an ethylenically unsaturated monomer, to a method of producing said particles, to the use of said particles as nanopigments and to polymer dispersions comprising said particles as nanopigments.

  本发明涉及一种一般式(I)的染料单体：A - X - R - O - C(O) - O - CH2- C(H) = CH2，其中A是染料分子，X和R均为可选的连接物。本发明还涉及包含所述染料单体和乙烯基不饱和单体的共聚物的颗粒，以及制备所述颗粒的方法，以及将所述颗粒用作纳米颜料的用途，以及包含所述颗粒作为纳米颜料的聚合物分散体。
• Coloured Particles for Electrophoretic Displays
  申请人：Fontana Margherita

  公开号：US20090296195A1

  公开（公告）日：2009-12-03

  The present invention discloses the use of functionalized particles as electrophoretic displaying particles, wherein the functionalized particles are SiO 2 , Al 2 O 3 or mixed SiO 2 and Al 2 O 3 particles comprising, covalently bound to an oxygen atom on the surface, a radical of formula (1), wherein R 1 and R 2 are independently of each other hydrogen, particle surface-O—, or a substituent, n is 1, 2, 3, 4, 5, 6, 7 or 8, B is the direct bond or a bridge member, and D is the residue of an organic chromophore.

  本发明揭示了功能化颗粒作为电泳显示颗粒的用途，其中功能化颗粒为SiO2、Al2O3或混合SiO2和Al2O3颗粒，其中这些颗粒通过共价键结合到表面上的氧原子，具有以下结构的自由基（1），其中R1和R2分别独立地为氢、颗粒表面-O-，或取代基，n为1、2、3、4、5、6、7或8，B为直接键或桥接成员，D为有机色团的残基。
• Process for Hair Dyeing Comprising Application of Composite Pigment
  申请人：Cremer Christian

  公开号：US20090217465A1

  公开（公告）日：2009-09-03

  Disclosed is a process for dyeing of keratin-containing fibers comprising treating the fibers with at least one functionalized particle comprising on the surface an organic chromophore which is bound via a bridge member, wherein the particles are based on SiO 2 , Al 2 O 3 or mixtures thereof, and the functionalized particles carry a positive charge.

  揭示了一种染色角蛋白含量纤维的方法，包括将纤维与至少一种功能化颗粒处理，该颗粒在表面具有通过桥接成员结合的有机色素，其中颗粒基于SiO2、Al2O3或它们的混合物，并且功能化颗粒带有正电荷。
• Synthesis and Duplex-Forming Property of Oligonucleotides Bearing a Novel Polyamine-Modified Intercalator at the Terminal or the Internal Position
  作者：Tomohisa Moriguchi、Hirokazu Sekiguchi、Makoto Tachibana、Kazuo Shinozuka

  DOI：10.1080/15257770600685982

  日期：2006.6

  Novel oligonucleotides bearing a polyamine-intercalator conjugate modified at the terminal or the internal position were reported. These modified oligonucleotides showed duplex-stabilization effect, and the thermodynamic analysis and the salt concentration dependency of the duplex stability revealed that the polyamine moiety also acted as the duplex stabilizer by neutralization of the phosphate negative charge.
• Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix
  作者：Takanori Miyashita、Noritake Matsumoto、Tomohisa Moriguchi、Kazuo Shinozuka

  DOI：10.1016/j.tetlet.2003.08.052

  日期：2003.9

  A novel phosphoramidite synthon of a dinucleoside phosphotriester unit bearing an intercalative moiety at its internucleotide linkage in a stereospecific manner was prepared and successfully incorporated into the middle portion of alpha,-beta chimeric oligoDNA. One of the resulting stereoisomeric chimera DNAs strongly enhances the thermal stability of an alternate-stranded triplex formed between the chimera and a double-stranded DNA. (C) 2003 Elsevier Ltd. All rights reserved.