Tert-butyl 3-(propylamino)but-2-enoate | 196399-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Tert-butyl 3-(propylamino)but-2-enoate
• 英文别名: tert-butyl 3-(propylamino)but-2-enoate
• CAS: 196399-06-1
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.293
• InChiKey: FCOVSLFWALWSBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 3-(propylamino)but-2-enoate 以 乙醇 为溶剂， 反应 7.0h， 生成 C₄₄H₃₆N₂O₈S₂
  参考文献：
  名称：

  Regioselective One-Pot Synthesis of Isochromenopyrroles Containing a Disulfide Bond

  摘要：

  Isochromenopyrroles containing a disulfide bond were prepared by reacting enamines, resulting from propylamine and -keto esters, with aryl isothiocyanates to give rise to an intermediate which is trapped by ninhydrin. The simple procedure, metal-catalyst-free and mild reaction conditions, good to excellent yields, and no column chromatography are important features of this protocol.

  DOI：

  10.1055/s-0033-1338644
• 作为产物：
  描述：

  正丙胺 、 乙酰乙酸叔丁酯 反应 1.0h， 生成 Tert-butyl 3-(propylamino)but-2-enoate
  参考文献：
  名称：

  Regioselective One-Pot Synthesis of Isochromenopyrroles Containing a Disulfide Bond

  摘要：

  Isochromenopyrroles containing a disulfide bond were prepared by reacting enamines, resulting from propylamine and -keto esters, with aryl isothiocyanates to give rise to an intermediate which is trapped by ninhydrin. The simple procedure, metal-catalyst-free and mild reaction conditions, good to excellent yields, and no column chromatography are important features of this protocol.

  DOI：

  10.1055/s-0033-1338644

文献信息

• Fully Diastereoselective Synthesis of Polysubstituted, Functionalized Piperidines and Decahydroquinolines Based on Multicomponent Reactions Catalyzed by Cerium(IV) Ammonium Nitrate
  作者：Padmakar A. Suryavanshi、Vellaisamy Sridharan、Swarupananda Maiti、J. Carlos Menéndez

  DOI：10.1002/chem.201402607

  日期：2014.7.7

  The cerium(IV) ammonium nitrate (CAN)‐catalyzed, three‐component reaction between primary amines, β‐dicarbonyl compounds, and α,β‐unsaturated aldehydes in ethanol heated to reflux, constitutes a general, one‐pot synthesis of 1,4‐dihydropyridines. Their reduction with sodium triacetoxyborohydride furnished piperidine derivatives bearing up to five substituents with full diastereoselectivity in a hitherto

  硝酸铈（IV）硝酸铵（CAN）催化的伯胺，β-二羰基化合物和乙醇中加热到回流的α，β-不饱和醛之间的三组分反应构成了一般的一锅法合成，即1， 4-二氢吡啶 用三乙酰氧基硼氢化钠将它们还原，得到具有多达五个取代基的哌啶衍生物，并且以迄今难以达到的立体化学排列具有完全非对映选择性。在与通常对还原敏感的几个官能团相容的温和还原条件下，反应进行时对映体纯度没有明显损失。八氢喹啉-5-酮衍生物是通过初始多组分反应的改良形式制备的，不适用于三乙酰氧基硼氢化钠介导的还原反应，