9-甲基-6-吡咯烷-1-基嘌呤-2-胺 | 920317-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 9-甲基-6-吡咯烷-1-基嘌呤-2-胺
• 英文名称: 9-methyl-6-pyrrolidin-1-yl-9H-purin-2-amine
• 英文别名: 9H-Purin-2-amine, 9-methyl-6-(1-pyrrolidinyl)-；9-methyl-6-pyrrolidin-1-ylpurin-2-amine
• CAS: 920317-06-2
• 化学式: C₁₀H₁₄N₆
• 分子量: 218.261
• InChiKey: QTQGPLRFSGYPHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9-甲基-6-吡咯烷-1-基嘌呤-2-胺 以 1,4-二氧六环 、 水 、 丙酮 为溶剂， 反应 168.0h， 生成 1,6-dimethyl-4-pyrrolidin-1-yl-1H-imidazo[2,1-b]purin-6-ium iodide
  参考文献：
  名称：

  Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts

  摘要：

  一系列新型三环、乙烯桥联嘌呤类似物从2-氨基-6-(取代氨基)-9-甲基嘌呤通过与氯乙醛环化合成，特别关注环化反应的区域选择性和荧光性质。这些类似物以及起始嘌呤均与碘甲烷烷基化，形成一类具有潜在生物活性的季铵盐。未发现显著的荧光或细胞静止效应。

  DOI：

  10.1135/cccc20060077
• 作为产物：
  描述：

  四氢吡咯 、 6-氯-9-甲基-9H-嘌呤-2-胺 以 乙醇 为溶剂， 以83%的产率得到9-甲基-6-吡咯烷-1-基嘌呤-2-胺
  参考文献：
  名称：

  Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts

  摘要：

  一系列新型三环、乙烯桥联嘌呤类似物从2-氨基-6-(取代氨基)-9-甲基嘌呤通过与氯乙醛环化合成，特别关注环化反应的区域选择性和荧光性质。这些类似物以及起始嘌呤均与碘甲烷烷基化，形成一类具有潜在生物活性的季铵盐。未发现显著的荧光或细胞静止效应。

  DOI：

  10.1135/cccc20060077

文献信息

• Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
  申请人：Atea Pharmaceuticals, Inc.

  公开号：US10711029B2

  公开（公告）日：2020-07-14

  Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, Formula IX and Formula X that are highly active against the HCV virus when administered in an effective amount to a host in need thereof. The host can be a human or any animal that carries the viral infection. Methods of treating a subject suffering from a condition related to viral infections are also provided.

  式I、式II、式III、式IV、式V、式VI、式VII、式VIII、式IX和式X化合物，当以有效量施用给需要的宿主时，对HCV病毒具有高度活性。宿主可以是人类或任何携带病毒感染的动物。还提供了治疗与病毒感染有关的病症的方法。
• BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-4'-FLUORO-N6-SUBSTITUTED-6-AMINO-2-SUBSTITUTED PURINE NUCLEOTIDES FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTION
  申请人：Atea Pharmaceuticals, Inc.

  公开号：US20190153017A1

  公开（公告）日：2019-05-23

  Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, Formula IX and Formula X that are highly active against the HCV virus when administered in an effective amount to a host in need thereof. The host can be a human or any animal that carries the viral infection. Methods of treating a subject suffering from a condition related to viral infections are also provided.
• Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts
  作者：Kateřina Hořejší、Radek Pohl、Antonín Holý

  DOI：10.1135/cccc20060077

  日期：——

  A novel series of tricyclic, etheno-bridged purine analogs was sythesized from 2-amino-6-(substituted amino)-9-methylpurines by cyclization with chloroacetaldehyde, with particular focus on the regioselectivity of the cyclization reaction and fluorescence properties. The analogs as well as the starting purines were alkylated with iodomethane, affording a new class of quaternary salts with potential biological activity. Neither significant fluorescence nor cytostatic effect was found.

  一系列新型三环、乙烯桥联嘌呤类似物从2-氨基-6-(取代氨基)-9-甲基嘌呤通过与氯乙醛环化合成，特别关注环化反应的区域选择性和荧光性质。这些类似物以及起始嘌呤均与碘甲烷烷基化，形成一类具有潜在生物活性的季铵盐。未发现显著的荧光或细胞静止效应。