Cyclohexancarbonsaeure-jodid | 79929-36-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: Cyclohexancarbonsaeure-jodid
• 英文别名: cyclohexanecarbonyl iodide
• CAS: 79929-36-5
• 化学式: C₇H₁₁IO
• 分子量: 238.068
• InChiKey: ULUQQIRUGGLYGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Cyclohexancarbonsaeure-jodid 、 乙醛 以88%的产率得到1-(cyclohexylcarbonyloxy)ethyl iodide
  参考文献：
  名称：

  Method for producing 1-iodoalkyl acylates

  摘要：

  一种1-碘烷基酰酸酯，可用作头孢菌素、青霉素等酯化反应的原料，通过以下方式制备：（1）使羧酸碘化物与醛反应，或（2）使羧酸氯化物与碘化氢盐反应，然后使生成的产物与醛反应，或（3）同时使羧酸氯化物、碘化氢盐和醛相互反应，以高纯度和高产率制备。

  公开号：

  US04593115A1
• 作为产物：
  描述：

  环己甲酰氯 在 sodium iodide 作用下， 以 乙腈 、 Petroleum ether 为溶剂， 以61%的产率得到Cyclohexancarbonsaeure-jodid
  参考文献：
  名称：

  Method for producing 1-iodoalkyl acylates

  摘要：

  一种1-碘烷基酰酸酯，可用作头孢菌素、青霉素等酯化反应的原料，通过以下方式制备：（1）使羧酸碘化物与醛反应，或（2）使羧酸氯化物与碘化氢盐反应，然后使生成的产物与醛反应，或（3）同时使羧酸氯化物、碘化氢盐和醛相互反应，以高纯度和高产率制备。

  公开号：

  US04593115A1

文献信息

• PROCESS FOR PRODUCTION OF RIBOFURANOSE DERIVATIVES
  申请人：API Corporation

  公开号：EP2210896A1

  公开（公告）日：2010-07-28

  It is an object of the present Invention to provide a process for producing 1,2,3-tri-O-acetyl-5-deoxy-ribofuranose in an industrially appropriate manner. The present invention provides a process for producing a 1,2,3-tri-O-acetyl-5-deoxy-ribofuranose which comprises hydrogenating a compound represented by the formula (1) or formula (2) in the presence of a metal catalyst: wherein P1 and P2 independently represent a hydrogen atom or an acyl group OP1 and OP2 may together form an acetal group, and R represents a hydrogen atom, an alkyl group, an aryl group, an aralkyl group, or an acyl group; wherein X1 represents Br or I, P3 and P4 independently represent a hydrogen atom or an acryl group, and R represents a hydrogen atom, an alkyl group, an aryl group, an aralkyl group, or an acyl group.

  本发明的目的是以工业适当的方式提供一种生产1,2,3-三-O-乙酰-5-去氧-核糖呋喃糖的方法。本发明提供了一种生产1,2,3-三-O-乙酰-5-去氧-核糖呋喃糖的方法，其包括在金属催化剂的存在下氢化由化合物表示的化合物（1）或化合物（2）：其中P1和P2独立地表示氢原子或酰基OP1和OP2可以共同形成缩醛基，R表示氢原子、烷基、芳基、芳基烷基或酰基；其中X1表示Br或I，P3和P4独立地表示氢原子或丙烯酰基，R表示氢原子、烷基、芳基、芳基烷基或酰基。
• METHOD FOR PRODUCING CYCLIC SULFONIC ACID ESTER AND INTERMEDIATE THEREOF
  申请人：Kuramoto Ayako

  公开号：US20120130089A1

  公开（公告）日：2012-05-24

  The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.

  本发明旨在提供一种高效的生产方法，该方法不仅能够以低成本和高产率获得环状磺酸酯（磺酮），而且能够在商业规模下稳定地生产磺酸酯（磺酮）。本发明涉及一种生产羟基磺酮的方法，包括第一步，其中将具有特定结构的二元醇和硫酰卤反应，以获得具有特定结构的环状亚磺酸酯，以及第二步，其中将环状亚磺酸酯与水或/和醇反应；一种生产具有特定结构的不饱和磺酮的方法，包括第三步，其中将具有特定结构的羟基磺酮与酸卤或酸酐反应，以获得中间体，随后用碱处理中间体；以及具有特定结构的环状亚磺酸酯。
• METHOD FOR PRODUCING FURANOSE DERIVATIVE
  申请人：Katsurada Manabu

  公开号：US20100105890A1

  公开（公告）日：2010-04-29

  An object of the present invention is to provide a industrially appropriate method for producing the β-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein β-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl- 1 -O-alkyl-ribofuranose and 2,3-di-O-acyl- 1 -O-alkyl-5-deoxy-ribofuranose.

  本发明的目的是提供一种工业上适用的方法，以高选择性和高产率生产核黄素糖苷衍生物的β-异构体。本发明提供了一种生产核黄素糖苷衍生物的方法，其中通过控制反应试剂的用量和/或使用劣质溶剂，在2,3,5-三-O-酰基-1-O-烷基-核黄素糖苷和2,3-二-O-酰基-1-O-烷基-5-去氧-核黄素糖苷的乙酰化反应中沉淀β-异构体。
• Quinolone Neuropeptide S Receptor Antagonists
  申请人：Barrow James C.

  公开号：US20110212946A1

  公开（公告）日：2011-09-01

  The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved.

  本发明涉及喹诺酮化合物，它们是神经肽S受体拮抗剂，可用于治疗或预防神经系统和精神疾病，以及涉及神经肽S受体的疾病。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在预防或治疗涉及神经肽S受体的疾病中的用途。
• AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
  申请人：BIAN Haiyan

  公开号：US20100324012A1

  公开（公告）日：2010-12-23

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R 1 , and s are defined herein.

  本发明涉及化合物、组合物和方法，用于治疗各种疾病、综合症、状况和障碍，包括疼痛。这些化合物由下式（I）所表示：其中Y、Z、R1和s在此定义。