Phenyl-2-thienyl ketone hydrazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenyl-2-thienyl ketone hydrazone
• 英文别名: [phenyl(thiophen-2-yl)methylidene]hydrazine
• 化学式: C₁₁H₁₀N₂S
• 分子量: 202.28
• InChiKey: XCDZXRQCFJDTQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Phenyl-2-thienyl ketone hydrazone 在 mercury oxide 作用下， 生成 (苯基)(2-噻吩基)重氮甲烷
  参考文献：
  名称：

  New Applications of Hetaryl Thioketones for the Synthesis of Hetaryl-Substituted Ethenes via ‘Two-Fold Extrusion Reaction’

  摘要：

  A series of aryl/hetaryl thioketones was applied for the reactions with aryl/hetaryldiazomethanes yielding, after elimination of N-2, the corresponding thiiranes. The relatively unstable dihetaryldiazomethanes were generated in situ from the corresponding hydrazones by oxidation with DMSO. The obtained thiiranes were converted into tetraaryl/hetaryl-substituted ethenes in good yields by desulfurization performed with tris(diethylamino)phosphine ((Et2N)(3)P).

  DOI：

  10.3987/com-15-s(t)8
• 作为产物：
  描述：

  2-苯甲酰噻吩 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 Phenyl-2-thienyl ketone hydrazone
  参考文献：
  名称：

  New Applications of Hetaryl Thioketones for the Synthesis of Hetaryl-Substituted Ethenes via ‘Two-Fold Extrusion Reaction’

  摘要：

  A series of aryl/hetaryl thioketones was applied for the reactions with aryl/hetaryldiazomethanes yielding, after elimination of N-2, the corresponding thiiranes. The relatively unstable dihetaryldiazomethanes were generated in situ from the corresponding hydrazones by oxidation with DMSO. The obtained thiiranes were converted into tetraaryl/hetaryl-substituted ethenes in good yields by desulfurization performed with tris(diethylamino)phosphine ((Et2N)(3)P).

  DOI：

  10.3987/com-15-s(t)8

文献信息

• Oxidation of hydrazones to the corresponding diazo compound
  申请人：Glaxo Laboratories Limited

  公开号：US04083837A1

  公开（公告）日：1978-04-11

  A process for the preparation of diazo compounds, particularly diazoalkanes, is described in which a hydrazone is oxidized with an oxidizing agent, said oxidizing agent comprising an organic peracid, chloramine-T or N-chlorosuccinimide to a corresponding diazo compound, preferably in the presence of a base. The reaction may be catalyzed by an oxidation catalyst such as iodine.

  本文描述了一种制备重氮化合物（特别是重氮烷基）的方法，其中通过使用有机过氧酸、氯胺-T或N-氯琥珀酰亚胺作为氧化剂，将酰肼氧化为相应的重氮化合物，最好在碱的存在下进行。该反应可由碘等氧化催化剂催化。
• New Applications of Hetaryl Thioketones for the Synthesis of Hetaryl-Substituted Ethenes via ‘Two-Fold Extrusion Reaction’
  作者：Heinz Heimgartner、Grzegorz Mlostoń、Katarzyna Urbaniak、Aneta Pawlak

  DOI：10.3987/com-15-s(t)8

  日期：——

  A series of aryl/hetaryl thioketones was applied for the reactions with aryl/hetaryldiazomethanes yielding, after elimination of N-2, the corresponding thiiranes. The relatively unstable dihetaryldiazomethanes were generated in situ from the corresponding hydrazones by oxidation with DMSO. The obtained thiiranes were converted into tetraaryl/hetaryl-substituted ethenes in good yields by desulfurization performed with tris(diethylamino)phosphine ((Et2N)(3)P).