[2-(4-Methylamino-butoxy)-phenyl]-phenyl-amine | 75859-84-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-(4-Methylamino-butoxy)-phenyl]-phenyl-amine
• 英文别名: 2-[4-(methylamino)butoxy]-N-phenylaniline
• CAS: 75859-84-6
• 化学式: C₁₇H₂₂N₂O
• 分子量: 270.374
• InChiKey: WUDGMOSYMZDVMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-苯胺基苯酚 在 氢氧化钾 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 32.0h， 生成 [2-(4-Methylamino-butoxy)-phenyl]-phenyl-amine
  参考文献：
  名称：

  Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives

  摘要：

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

  DOI：

  10.1021/jm00134a004

文献信息

• Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives
  作者：Ryoji Kikumoto、Akihiro Tobe、Shinji Tonomura

  DOI：10.1021/jm00134a004

  日期：1981.2

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.