N-(4-羟基苯基)-2-甲基苯甲酰胺 | 22978-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-羟基苯基)-2-甲基苯甲酰胺
• 英文名称: 4'-Hydroxy-2-methylbenzanilid
• 英文别名: 2-Methyl-4'-hydroxybenzanilid；N-(4-Hydroxyphenyl)-2-methylbenzamide
• CAS: 22978-52-5
• 化学式: C₁₄H₁₃NO₂
• mdl: MFCD00442149
• 分子量: 227.263
• InChiKey: OGBLLVHAQZADRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  四氢吡咯 、 聚合甲醛 、 N-(4-羟基苯基)-2-甲基苯甲酰胺 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 N-[4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)phenyl]-2-methylbenzamide
  参考文献：
  名称：

  Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides

  摘要：

  Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the amides were found to be potent antiarrhythmic agents that possessed low parasympatholytic activity. All of the compounds appear to act by a class I mechanism.

  DOI：

  10.1021/jm00376a022
• 作为产物：
  描述：

  对氨基苯酚 、 邻甲基苯甲酰氯 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 N-(4-羟基苯基)-2-甲基苯甲酰胺
  参考文献：
  名称：

  Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides

  摘要：

  Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the amides were found to be potent antiarrhythmic agents that possessed low parasympatholytic activity. All of the compounds appear to act by a class I mechanism.

  DOI：

  10.1021/jm00376a022

文献信息

• US3937840A
  申请人：——

  公开号：US3937840A

  公开（公告）日：1976-02-10
• US3985804A
  申请人：——

  公开号：US3985804A

  公开（公告）日：1976-10-12
• Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides
  作者：David M. Stout、W. L. Matier、Cynthia Barcelon-Yang、Robert D. Reynolds、Barry S. Brown

  DOI：10.1021/jm00376a022

  日期：1984.10

  Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the amides were found to be potent antiarrhythmic agents that possessed low parasympatholytic activity. All of the compounds appear to act by a class I mechanism.