cis-4-Phenylcyclohexanolmethylether | 64422-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-4-Phenylcyclohexanolmethylether
• CAS: 64422-95-3
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: ISSFAAFZIJMWHN-BETUJISGSA-N

物化性质

• 沸点：
  273.7±29.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  cis-4-Phenylcyclohexanolmethylether 在 lithium phosphate 、 氘代丙酮 、 C₁₀H₁₂Cl₂F₃Rh 、 双三氟甲烷磺酰亚胺银盐 作用下， 反应 24.0h， 以89%的产率得到
  参考文献：
  名称：

  铑催化的可逆 η6 配位对苄基 C-H 键的立体选择性氘化

  摘要：

  报道了通过 η 6配位策略实现伯、仲和叔苄基 C-H 键的新型铑催化 H/D 交换。该方法具有高区域选择性和立体保留性，具有广泛的官能团耐受性，已用于药物的后期标记。

  DOI：

  10.1002/anie.202117381
• 作为产物：
  描述：

  4-甲氧基联苯 在 镍 氢气 作用下， 以 乙醇 为溶剂， 50.0 ℃ 、50.0 kPa 条件下， 反应 5.0h， 生成 1-环己基-4-甲氧基苯 、 trans-(4-methoxycyclohexyl)benzene 、 cis-4-Phenylcyclohexanolmethylether 、 4-methoxy-1,1'-bis(cyclohexane) 、 4-methoxy-1,1'-bis(cyclohexane)
  参考文献：
  名称：

  Hydrogenation of 4-substituted biphenyls

  摘要：

  DOI：

  10.1021/jo00385a018

文献信息

• A mild method for eliminating alkyl ethers to alkenes
  作者：Stephanie Lindner、Stefan Bräse

  DOI：10.1039/c4ra03785e

  日期：——

  A method for the conversion of methyl ethers into alkenes is described. In a one-step and mild procedure, both conjugated and isolated cyclic alkenes are accessible in mostly good yields using triflic anhydride in combination with triethylamine. This elimination procedure can also be applied to ethyl and benzyl ethers.

  本文介绍了一种将甲基醚转化为烯的方法。在一个步骤和温和的程序中，使用三酸酐和三乙胺可以获得共轭烯烃和分离环烯烃，而且大部分产量都很高。这种消除过程也适用于乙基和苄基醚。
• SUBSTITUTED PIPERIDINO COMPOUNDS AND RELATED METHODS OF TREATMENT
  申请人：Alkermes, Inc.

  公开号：US20220194926A1

  公开（公告）日：2022-06-23

  The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

  本发明提供了一种用于治疗需要治疗嗜睡症或弛缓症患者的化合物。此外，还提供了相关的制药组合物和方法。
• [EN] 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS<br/>[FR] AGONISTES 3-HÉTÉROARYL PYRROLIDINE ET PIPÉRIDINE DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2022119888A1

  公开（公告）日：2022-06-09

  The present invention is directed to 3-heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及3-杂环芳基吡咯烷和哌嗪化合物，其是促进觉醒素受体的激动剂。本发明还涉及这些化合物在潜在的神经和精神障碍和疾病的治疗或预防中的用途，其中涉及觉醒素受体。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在预防或治疗涉及觉醒素受体的疾病中的潜在用途。
• [EN] 5-ALKYL PYRROLIDINE OREXIN RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'OREXINE 5-ALKYL-PYRROLIDINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2020167706A1

  公开（公告）日：2020-08-20

  The present invention is directed to 5-alkyl pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
• Rhodium‐Catalyzed Stereoselective Deuteration of Benzylic C–H Bonds via Reversible η ⁶ ‐Coordination
  作者：Qi‐Kai Kang、Yuntong Li、Kai Chen、Hui Zhu、Wen‐Qiang Wu、Yunzhi Lin、Hang Shi

  DOI：10.1002/anie.202117381

  日期：2022.3.7

  A novel rhodium-catalyzed H/D exchange of primary, secondary, and tertiary benzylic C−H bonds by means of an η6-coordination strategy is reported. The method, which features high regioselectivity and stereoretention, shows broad functional group tolerance and has been used in late-stage labeling of pharmaceuticals.

  报道了通过 η 6配位策略实现伯、仲和叔苄基 C-H 键的新型铑催化 H/D 交换。该方法具有高区域选择性和立体保留性，具有广泛的官能团耐受性，已用于药物的后期标记。