2,2',6,6'-(4,4'-bipyridine)tetracarboxylic acid chloride | 124558-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2',6,6'-(4,4'-bipyridine)tetracarboxylic acid chloride
• 英文别名: 2,2',6,6'-Tetrachloroformyl-4,4'-bipyridine；[4,4'-bipyridine]-2,2',6,6'-tetracarbonyl chloride；[4,4'-Bipyridine]-2,2',6,6'-tetracarbonyl tetrachloride；4-(2,6-dicarbonochloridoylpyridin-4-yl)pyridine-2,6-dicarbonyl chloride
• CAS: 124558-61-8
• 化学式: C₁₄H₄Cl₄N₂O₄
• 分子量: 406.009
• InChiKey: WGECVALPVQOISD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙醇 、 3-叔丁基-吡唑-5-胺 、 2,2',6,6'-(4,4'-bipyridine)tetracarboxylic acid chloride 以 甲苯 、 水 为溶剂， 以66%的产率得到N2,N2',N6,N6'-tetrakis(5-(tert-butyl)-1H-pyrazol-3-yl)-[4,4'-bipyridine]-2,2',6,6'-tetracarboxamide hydrate ethanol solvate
  参考文献：
  名称：

  Saddling up copper – new twists on a metallo-wheel

  摘要：

  一种由大型、灵活的多齿配体组装而成的八核铜（II）簇呈现出一种不寻常的马鞍形结构拓扑。

  DOI：

  10.1039/c3dt53267d
• 作为产物：
  描述：

  3,3',6,6'-四羧酸-4,4'-联吡啶 在 氯化亚砜 作用下， 反应 5.0h， 生成 2,2',6,6'-(4,4'-bipyridine)tetracarboxylic acid chloride
  参考文献：
  名称：

  Saddling up copper – new twists on a metallo-wheel

  摘要：

  一种由大型、灵活的多齿配体组装而成的八核铜（II）簇呈现出一种不寻常的马鞍形结构拓扑。

  DOI：

  10.1039/c3dt53267d

文献信息

• Novel CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications
  申请人：Zheng Zhongli

  公开号：US20070249682A1

  公开（公告）日：2007-10-25

  The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.

  本发明涉及新型CD40：CD154结合中断化合物的使用以及包含这些化合物的制药组合物，用于治疗与主体中不适当的CD154激活有关的疾病。具体而言，本发明提供了通过筛选小分子库以鉴定能够特异性结合CD154并中断CD40：CD154相互作用的化合物。
• Huenig, Siegfried; Wehner, Ingeborg, Synthesis, 1989, # 7, p. 552 - 554
  作者：Huenig, Siegfried、Wehner, Ingeborg

  DOI：——

  日期：——
• The activated core approach to combinatorial chemistry: A selection of new core molecules
  作者：Kent E. Pryor、Gerald W. Shipps、David A. Skyler、Julius Rebek

  DOI：10.1016/s0040-4020(98)00139-2

  日期：1998.4

  Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space and increase the structural diversity of prepared libraries, as well as to incorporate recognition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies used to simplify complex libraries and build individual molecular species based on the cores are also provided. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
• HUNIG, SIEGFRIED;WEHNER, INGEBORG, SYNTHESIS,(1989) N, C. 552-554
  作者：HUNIG, SIEGFRIED、WEHNER, INGEBORG

  DOI：——

  日期：——
• US7173046B2
  申请人：——

  公开号：US7173046B2

  公开（公告）日：2007-02-06