10H-Pyrimido<5.4-b><1.4>benzothiazin | 261-98-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 10H-Pyrimido<5.4-b><1.4>benzothiazin
• 英文别名: 10H-Pyrimido[5,4-b][1,4]benzothiazine
• CAS: 261-98-3
• 化学式: C₁₀H₇N₃S
• 分子量: 201.252
• InChiKey: LHJNPGJSDAVCHR-UHFFFAOYSA-N

物化性质

• 沸点：
  419.3±14.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)
• 熔点：
  185-186 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-Chlor-10H-pyrimido-<5.4-b><1.4>benzothiazin 在 一水合肼 、 copper(II) sulfate 作用下， 以 盐酸 、 乙二醇甲醚 、 水 为溶剂， 反应 7.0h， 生成 10H-Pyrimido<5.4-b><1.4>benzothiazin
  参考文献：
  名称：

  5-Arylthiopyrimidines. III. Cyclization of 4-Hydroxy Derivatives to 10H-Pyrimido[5,4-b][1,4]benzothiazines (1,3-Diazaphenothiazines)¹

  摘要：

  DOI：

  10.1021/jo01045a042

文献信息

• METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING
  申请人：TOMIC Marjana

  公开号：US20090068251A1

  公开（公告）日：2009-03-12

  Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.
• METHODS FOR TREATING PATHOLOGICAL NEOVASCULARIZATION
  申请人：Blobel Carl P.

  公开号：US20090285840A1

  公开（公告）日：2009-11-19

  Provided herein are compositions and methods that inhibit expression of Adam9 gene products, such as ADAM9 mRNA and/or ADAM9 polypeptides, as a therapeutic approach for the treatment of pathological neovascularization and conditions associated with angiogenesis.
• [EN] METHOD OF PRODUCING PURE AMIDITES AND OLIGONUCLEOTIDES<br/>[FR] PROCEDE DE PRODUCTION D'AMIDITES PURES ET D'OLIGONUCLEOTIDES
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2004113553A2

  公开（公告）日：2004-12-29

  The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for making high quality phosphoramidites and oligonucleotides derived therefrom. In some embodiments, the methods comprise identifiying and measuring one or more signals corresponding to one or more critical or non-critical impurities in an amidite sample, and accepting or rejecting the amidite sample depending upon whether the amount of the critical or non-critical impurity is less than or equal to a predetermined threshold.
• 5-Arylthiopyrimidines. III. Cyclization of 4-Hydroxy Derivatives to 10H-Pyrimido[5,4-b][1,4]benzothiazines (1,3-Diazaphenothiazines)¹
  作者：Barbara Roth、Lorraine A. Schloemer

  DOI：10.1021/jo01045a042

  日期：1963.10