2-(S)-(1,3-dioxobutyl)oxypropyl propenoate | 290834-74-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-(S)-(1,3-dioxobutyl)oxypropyl propenoate
• 英文别名: [(2S)-1-prop-2-enoyloxypropan-2-yl] 3-oxobutanoate
• CAS: 290834-74-1
• 化学式: C₁₀H₁₄O₅
• 分子量: 214.218
• InChiKey: NGZDFOYYIXAAPC-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  15.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.67
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(S)-(1,3-dioxobutyl)oxypropyl propenoate 在 磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 2-(S)-(1,3-dioxo-2-chlorobutyl)oxypropyl propenoate
  参考文献：
  名称：

  Diastereoselective synthesis of bis(3,5)pyrazolophanes by sequential inter- and intramolecular cycloadditions of homochiral nitrilimines

  摘要：

  Starting from ethyl (S)-lactate as the chiral unit, we have developed the synthesis of the enantiopure bis(3,5)pyrazolophanes 9 and 19 by means of sequential inter- and intramolecular cycloadditions of nitrilimine intermediates. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00132-4
• 作为产物：
  描述：

  2-(S)-(tetrahydropyranyl)oxypropyl propenoate 在 盐酸 作用下， 以 甲醇 、 xylene 为溶剂， 反应 2.5h， 生成 2-(S)-(1,3-dioxobutyl)oxypropyl propenoate
  参考文献：
  名称：

  Diastereoselective synthesis of bis(3,5)pyrazolophanes by sequential inter- and intramolecular cycloadditions of homochiral nitrilimines

  摘要：

  Starting from ethyl (S)-lactate as the chiral unit, we have developed the synthesis of the enantiopure bis(3,5)pyrazolophanes 9 and 19 by means of sequential inter- and intramolecular cycloadditions of nitrilimine intermediates. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00132-4

文献信息

• Diastereoselective synthesis of bis(3,5)pyrazolophanes by sequential inter- and intramolecular cycloadditions of homochiral nitrilimines
  作者：Gianluigi Broggini、Giorgio Molteni、Tullio Pilati

  DOI：10.1016/s0957-4166(00)00132-4

  日期：2000.5

  Starting from ethyl (S)-lactate as the chiral unit, we have developed the synthesis of the enantiopure bis(3,5)pyrazolophanes 9 and 19 by means of sequential inter- and intramolecular cycloadditions of nitrilimine intermediates. (C) 2000 Elsevier Science Ltd. All rights reserved.