2,3,4-三氟氯卞 | 292621-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4-三氟氯卞
• 中文别名: 2,3,4-三氟苄氯
• 英文名称: trifluorobenzyl chloride
• 英文别名: 1-(Chloromethyl)-2,3,4-trifluorobenzene
• CAS: 292621-60-4
• 化学式: C₇H₄ClF₃
• mdl: MFCD03001152
• 分子量: 180.557
• InChiKey: RLWBYURQFNYMIW-UHFFFAOYSA-N

物化性质

• 沸点：
  177.1±35.0 °C(Predicted)
• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  2,3,4-三氟氯卞 在 硫脲 、 盐酸 、 N-氯代丁二酰亚胺 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 4.25h， 生成 C₇H₄ClF₃O₂S
  参考文献：
  名称：

  Palladium-Catalyzed Remotemeta-Selective C–H Bond Silylation and Germanylation

  摘要：

  Selective meta-C-H activation of arenes to date has met with a limited number of functionalizations. Expanding the horizon of meta-C-H functionalization, herein we disclose an unprecedented meta-silylation and -germanylation protocol by employing a simple nitrile-based directing template. Longer linkers between the target site and the directing template were successfully explored for meta-silylation (sp(2)-epsilon and sp(2)-zeta). Additionally, synthetic utility was demonstrated with several postsynthetic elaborations and with a formal synthesis of TAC101, a promising drug for the treatment of lung cancer.

  DOI：

  10.1021/acs.organomet.7b00309

文献信息

• N-vinylimidazolidine derivatives insecticides containing same as an
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US05310920A1

  公开（公告）日：1994-05-10

  The present invention relates to novel N-vinylimidazolidine derivatives of the following formula (1), a process for producing them, an insecticide containing the derivatives as an effective ingredient, and novelintermediates. The derivatives (1) are useful as agricultural chemicals (particularly, as insecticides) in the fields of agriculture, and the intermediates are useful in various industrial fields, especially as intermediates for agricultural chemicals. ##STR1## where R.sup.1, R.sup.2, Z are as defined in the specification.

  本发明涉及具有以下通式(1)的新型N-乙烯基咪唑烷衍生物、其制备方法、含有该衍生物作为有效成分的杀虫剂以及新型中间体。这些衍生物(1)在农业领域中作为农用化学品(特别是杀虫剂)具有用途，而中间体在各种工业领域中，尤其是作为农用化学品的中间体具有用途。 ##STR1## 其中R1、R2、Z的定义如说明书中所述。
• Fluorine atom containing benzyl ketone compound and process for producing the same
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1609774A1

  公开（公告）日：2005-12-28

  The invention relates to a fluorine atom containing benzyl ketone compound represented by the following formula (1), wherein R1 denotes methyl, ethyl, propyl, methoxy, or ethoxy, X1 denotes a fluorine atom or tri-fluoro methoxy, R2 denotes 1,4-cyclohexylene, or 1,4-phenylene, R3 denotes an aliphatic hydrocarbon group having 1 to 10 carbon atoms, 1 means an integer of 0 or 1, m means an integer of 0 or 1, and n means an integer of 1 to 3, which compound is quite useful as intermediate for the preparation of a liquid crystaline material. Furthermore, the compound can be obtained by a simple process of the present invention in high yield and selectivity, wherein the process comprises; reacting a fluorine atom containing benzyl haloid with an aliphatic hydrocarbon group containing cyclohexyl carbonyl chloride in the presence of Pd catalyst and zinc powder under an oxgen-free atmosphere.

  该发明涉及一种由以下化学式（1）表示的含氟苄基酮化合物，其中R1代表甲基、乙基、丙基、甲氧基或乙氧基，X1代表氟原子或三氟甲氧基，R2代表1,4-环己亚甲基或1,4-苯亚甲基，R3代表具有1至10个碳原子的脂肪烃基，1表示0或1的整数，m表示0或1的整数，n表示1至3的整数，该化合物作为液晶材料的制备中间体非常有用。此外，该化合物可以通过本发明的简单工艺高产高选择性地获得，其中该工艺包括：在无氧气氛下，在存在Pd催化剂和锌粉的情况下，将含氟苄卤与含环己基羰基氯的脂肪烃基反应。
• FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20190031600A1

  公开（公告）日：2019-01-31

  Provided is a fluorine atom-containing compound represented by formula (1) below (In the formula, Z represents a predetermined divalent group, each Ar independently represents a predetermined aromatic ring-containing group, and each Ar F independently represents a predetermined fluorine atom-containing aryl group).

  提供的是下面公式（1）所代表的含氟原子的化合物（在公式中，Z代表预定的二价基团，每个Ar独立代表预定的含芳香环的基团，每个ArF独立代表预定的含氟原子的芳基基团）。
• Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1686119A1

  公开（公告）日：2006-08-02

  Pyrimidinone compounds of formula (I) are inhibitors of the enzyme LpPLA2 and are useful in the treatment of atherosclerosis

  式 (I) 的嘧啶酮化合物是 LpPLA2 酶的抑制剂，可用于治疗动脉粥样硬化症
• Fluorine atom-containing compound and use thereof
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10336686B2

  公开（公告）日：2019-07-02

  Provided is a fluorine atom-containing compound represented by formula (1) below (In the formula, Z represents a predetermined divalent group, each Ar independently represents a predetermined aromatic ring-containing group, and each ArF independently represents a predetermined fluorine atom-containing aryl group).

  本发明提供了由下式（1）表示的含氟原子化合物 (式中，Z 代表预定的二价基团，每个 Ar 独立地代表预定的含芳香环基团，每个 ArF 独立地代表预定的含氟原子的芳基）。