Methyl 1-(3-methoxypropyl)-5-oxopyrrolidine-3-carboxylate | 910443-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Methyl 1-(3-methoxypropyl)-5-oxopyrrolidine-3-carboxylate
• CAS: 910443-38-8
• 化学式: C₁₀H₁₇NO₄
• 分子量: 215.249
• InChiKey: ILSXGNQUTQBJSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  衣康酸二甲酯 、 3-甲氧基丙胺 生成 Methyl 1-(3-methoxypropyl)-5-oxopyrrolidine-3-carboxylate
  参考文献：
  名称：

  Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor

  摘要：

  Based on a lead compound identified from the patent literature, we developed patentably novel BACE-1 inhibitors by introducing a cyclic amine scaffold as embodied by la and 1b. Extensive SAR studies assessed a variety of isophthalamide replacements including substituted pyrrolidinones and ultimately led to the identification of 11. Due to its favorable overall profile, 11 has been extensively profiled in various in vivo settings. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.053

文献信息

• COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS
  申请人：L'Oréal

  公开号：EP2579841B1

  公开（公告）日：2016-09-14
• US8771376B2
  申请人：——

  公开号：US8771376B2

  公开（公告）日：2014-07-08
• [EN] COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS<br/>[FR] COMPOSITION COMPRENANT AU MOINS UNE 2-PYRROLIDONE FONCTIONNALISÉE AVEC UN RADICAL AMIDE OU ESTER, ET AU MOINS UN PIGMENT OU UN COLORANT DIRECT, POUR LA TEINTURE DE MATÉRIAUX KÉRATINIQUES
  申请人：OREAL

  公开号：WO2011154458A1

  公开（公告）日：2011-12-15

  The invention relates to a composition for dyeing keratin materials, and in particular human keratin fibres such as the hair, comprising at least one 2-pyrrolidone functionalized in the 4 position with an ester or amide radical, and at least one hydrophobic direct dye or a pigment; a dyeing process using this composition. Similarly, the invention relates to the use of the said pyrrolidone combined with a direct dye or a pigment for dyeing keratin materials, and especially to the use of the said pyrrolidone for improving the colour uptake onto the fibres of direct dyes that are sparingly soluble or insoluble in aqueous-alcoholic supports. The invention also relates to novel pyrrolidone derivatives. The present invention makes it possible in particular to obtain direct dyeing on keratin materials that is fast, resistant to washing, chromatic and powerful.
• Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor
  作者：U. Iserloh、J. Pan、A.W. Stamford、M.E. Kennedy、Q. Zhang、L. Zhang、E.M. Parker、N.A. McHugh、L. Favreau、C. Strickland、J. Voigt

  DOI：10.1016/j.bmcl.2007.10.053

  日期：2008.1

  Based on a lead compound identified from the patent literature, we developed patentably novel BACE-1 inhibitors by introducing a cyclic amine scaffold as embodied by la and 1b. Extensive SAR studies assessed a variety of isophthalamide replacements including substituted pyrrolidinones and ultimately led to the identification of 11. Due to its favorable overall profile, 11 has been extensively profiled in various in vivo settings. (c) 2007 Elsevier Ltd. All rights reserved.