N¹,N²-bis(3-nitrobenzylidene)phenylene diamine | 15223-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N²-bis(3-nitrobenzylidene)phenylene diamine
• 英文别名: N,N'-bis[(E)-(3-nitrophenyl)methylidene]benzene-1,2-diamine；1-(3-nitrophenyl)-N-[2-[(3-nitrophenyl)methylideneamino]phenyl]methanimine
• CAS: 15223-26-4
• 化学式: C₂₀H₁₄N₄O₄
• 分子量: 374.356
• InChiKey: GKJJLRHVPQXBTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N¹,N²-bis(3-nitrobenzylidene)phenylene diamine 在 对甲苯磺酸 作用下， 以 neat (no solvent) 为溶剂， 以93%的产率得到1-(3-nitrobenzyl)-2-(3-nitrophenyl)-1H-benzimidazole
  参考文献：
  名称：

  Facile Synthesis of 1,2-Disubstituted Benzimidazoles Usingp-Toluenesulfonic Acid through Grinding Method

  摘要：

  An efficient synthetic method for the highly selective synthesis of pharmacologically active 1,2-disubstituted benzimidazole derivatives fromo-phenylenediamine and various aromatic aldehydes catalyzed byp-toluenesulfonic acid through grinding under solvent-free condition is described. The reaction requires the catalyst only during the conversion of intermediateN,N '-dibenzylidene-o-phenylenediamine into the desired product. The products were obtained within a short time with good yields by using only a mortar and pestle, which makes the proposed method convenient and cost-effective.

  DOI：

  10.1134/s1070428020090201
• 作为产物：
  描述：

  间硝基苯甲醛 、 邻苯二胺 在 γ-maghemite-silica nanocomposite from 20 mg FeCl3/g silica activated 作用下， 以 neat (no solvent) 为溶剂， 生成 N¹,N²-bis(3-nitrobenzylidene)phenylene diamine
  参考文献：
  名称：

  γ-Maghemite-silica nanocomposite: A green catalyst for diverse aromatic N-heterocycles

  摘要：

  gamma-Maghemite-silica nanocomposite has been applied as a green catalyst to synthesize variety of aromatic N-heterocycles under solvent free conditions. Characterization was done by modern analytical tools (UV, IR, AAS, DSC, EDXRF, powdered XRD, EPR, Mossbauer and TEM). Mild reaction conditions and recyclability have made the present protocol both environmentally and economically viable. (c) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2013.06.026

文献信息

• Synthesis and antimicrobial activity of tris phosphonates
  作者：B. Siva Kumar、M. Veera Narayana Reddy、G. Chandra Sekhar Reddy、N. Bakthavatchala Reddy、C. Suresh Reddy

  DOI：10.1002/jhet.530

  日期：2011.1

  Syntheses of novel [(3‐dialkoxy‐phosphoryl)‐(substituted‐phenyl‐methyl)‐2‐oxo‐2‐phenyl‐2,3‐dihydro‐2λ5–benzo [1,3,2] diazaphosphol‐1‐yl}‐(substituted‐phenyl)‐methyl]‐phosphonic acid diethyl/dimethyl esters (3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j) were conveniently accomplished by cyclocondensation of [(2‐(dimethoxy‐phosphoryl)‐phenyl‐methyl)‐amino}‐phenyl amino)‐phenyl‐methyl]phosphonic acid diethyl/dimethyl

  新颖的合成[（3-二烷氧基-磷酰基） - （取代的-苯基-甲基）-2-氧代-2-苯基-2,3-二氢- 2λ 5 -苯并[1,3,2] diazaphosphol -1- yl}-（取代的苯基）-甲基]-膦酸二乙基/二甲基酯（3a，3b，3c，3d，3e，3f，3g，3h，3i，3j）可通过[[2- [ （二甲氧基-磷酰基）-苯基-甲基）-氨基}-苯基氨基）-苯基-甲基]膦酸二乙基/二甲酯（2a，2b，2c，2d，2e在三乙胺存在下于40°C的条件下，用无水甲苯中的二氯苯基膦酸（2f，2g，2h，2h，2i，2j）。通过物理光谱技术表征标题化合物。发现所有合成的化合物都具有抗菌性能。J.杂环化​​学.2011。