(L-alanyl-L-phenylalanylamino)-methylphosphonic acid | 60668-63-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (L-alanyl-L-phenylalanylamino)-methylphosphonic acid
• 英文别名: [[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]methylphosphonic acid
• CAS: 60668-63-5
• 化学式: C₁₃H₂₀N₃O₅P
• 分子量: 329.293
• InChiKey: AMMSDBYPWBXCLF-ONGXEEELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  acide L-phenylalanyl-aminomethylphosphonique 生成 (L-alanyl-L-phenylalanylamino)-methylphosphonic acid
  参考文献：
  名称：

  CH624965

  摘要：

  公开号：

文献信息

• SELECTIVE GROWTH MEDIA
  申请人：The Newcastle upon Tyne Hospitals National Health Service Trust

  公开号：EP1325024A1

  公开（公告）日：2003-07-09
• US4100275A
  申请人：——

  公开号：US4100275A

  公开（公告）日：1978-07-11
• US4127649A
  申请人：——

  公开号：US4127649A

  公开（公告）日：1978-11-28
• US4134972A
  申请人：——

  公开号：US4134972A

  公开（公告）日：1979-01-16
• [EN] SELECTIVE GROWTH MEDIA<br/>[FR] MILIEU DE CROISSANCE SELECTIF
  申请人：NEWCASTLE UPON TYNE HOSPITALS

  公开号：WO2002024725A1

  公开（公告）日：2002-03-28

  Selective bacterial growth media can be used to screen a mixture of bacteria for the target species of interest in which the target species grow but the commensal bacteria are inhibited. The novel media components are pro-inhibitors which are present as non-toxic precursors, which are taken up by and chemically altered, e.g. by an enzyme or some other metabolic process, to release the antibacterial products in commercial bacteria. The target species, however, are capable of growing in the medium. The preferred embodiment provided uses peptidyl or aminoacyl derivatives of an antibacterial agent. Suitably the antibacterial agent is fosfalin (1-aminoethylphosphonic acid) and the derivative is alafosfalin (L-alanyl-1-aminoethylphosphonic acid). This suicide substrate inhibits growth in commensal bacterial such as E.coli when screening for Salmonella species.