1(2)H-pyrazolo[3,4-f]quinoline | 233-43-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1(2)H-pyrazolo[3,4-f]quinoline
• 英文别名: 1(2)H-Pyrazolo[3,4-f]chinolin；1H-Pyrazolo<3,4-f>chinolin；Pyridoindazole；1H-pyrazolo[3,4-f]quinoline
• CAS: 233-43-2
• 化学式: C₁₀H₇N₃
• mdl: MFCD18447747
• 分子量: 169.186
• InChiKey: HWZJQLSBBQLPAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-氨基吲唑 在 硫酸 、 arsenic(III) trioxide 、 甘油 作用下， 生成 1(2)H-pyrazolo[3,4-f]quinoline
  参考文献：
  名称：

  Primc et al., Journal of Heterocyclic Chemistry, 1976, vol. 13, p. 899

  摘要：

  DOI：

文献信息

• [EN] ORAL COMPLEMENT FACTOR D INHIBITORS<br/>[FR] INHIBITEURS ORAUX DU FACTEUR D DU COMPLÉMENT
  申请人：BIOCRYST PHARM INC

  公开号：WO2021072198A1

  公开（公告）日：2021-04-15

  Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

  揭示了式(I)的化合物及其药学上可接受的盐，这些化合物是裂解系统的抑制剂。还提供了包含这种化合物的药物组合物，以及使用这些化合物和组合物治疗或预防由异常裂解系统活性特征的疾病或状况的方法。
• Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0260642A2

  公开（公告）日：1988-03-23

  Hetero [f] fused carbocyclic pyridines of the formula I are described, as well as processes for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

  描述了式 I 的杂[f]融合碳环吡啶及其制备工艺和药物组合物。 描述了其作为多巴胺激动剂对突触前多巴胺受体具有选择性的作用，可用作多巴胺能药、抗精神病药和抗高血压药以及治疗高泌乳素血症相关疾病和中枢神经系统疾病。
• Enzymatic encoding methods for efficient synthesis of large libraries
  申请人：Nuevolution A/S

  公开号：EP2341140A1

  公开（公告）日：2011-07-06

  Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

  本发明公开了一种获得双功能复合物的方法，该复合物由与单链标识寡核苷酸相连的分子组成，其中包含化学反应位点和用于酶加标记的引物位点的新生双功能复合物 a) 在化学反应位点与一种或多种反应物反应，b) 在引物位点与一种或多种标识反应物的标记进行酶反应。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• Fries, Justus Liebigs Annalen der Chemie, 1927, vol. 454, p. 306
  作者：Fries

  DOI：——

  日期：——