4-(3,5-di-tert-butyl-4-hydroxyphenyl)butanol | 3673-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3,5-di-tert-butyl-4-hydroxyphenyl)butanol
• 英文别名: 4-(4-Hydroxy-3,5-di-tert.-butyl-phenyl)-butan-1-ol；4-(4-hydroxybutyl)-2,6-di-tert-butylphenol；4-(4-hydroxy-3,5-di-tert-butylphenyl)butanol；4-(3,5-di-t-butyl-4-hydroxyphenyl)butanol；1-(4-Hydroxy-3,5-di-t-butylphenyl)-4-butanol；2,6-ditert-butyl-4-(4-hydroxybutyl)phenol
• CAS: 3673-69-6
• 化学式: C₁₈H₃₀O₂
• 分子量: 278.435
• InChiKey: SSPJNAQYNQFRDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3,5-di-tert-butyl-4-hydroxyphenyl)butanol 在 氢溴酸 作用下， 以91%的产率得到4-(4-hydroxyphenyl)butyl bromide
  参考文献：
  名称：

  官能取代的 4-烷基-2,6-二叔丁基苯酚与氢卤酸的相互作用

  摘要：

  研究了在其对位取代基中含有 OH、SH、COOH 和 COOMe 基团的 4-烷基-2,6-二叔丁基苯酚与氯化氢和氢卤酸的反应。2,6-二叔丁基-4-(ω-羟烷基)苯酚一步转化为相应的4-(ω-卤代烷基)苯酚，以及3-(3,5-二-叔-提出了丁基-4-羟基苯基丙酸及其酯类植物草酸。4-(3-巯基丙基)苯酚与浓加热。HBr 缩合为 3-(4-羟基苯基) 丙基 4-(3-巯基丙基) 苯基硫醚作为主要产物。

  DOI：

  10.1007/s11172-007-0169-y
• 作为产物：
  描述：

  1,4-丁二醇 、 2,6-二叔丁基苯酚 在 zinc(II) oxide 、 sodium hydroxide 作用下， 反应 5.0h， 以8%的产率得到1,4-bis-(3,5-di-tert-butyl-4-oxyphenyl)butane
  参考文献：
  名称：

  Synthesis of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols and the properties of related sulfides

  摘要：

  Reaction of 2,6-di-tert-butylphenol with aliphatic linear and branched diols in an alkaline medium at a temperature of 180-220A degrees C leads to the formation of 4-(omega-hydroxyalkyl)-2,6-di-tert-butylphenols. The increase in the product yield and reducing the reaction temperature was reached at the catalysis of this reaction with zinc oxide. The structure of the diphenylalkane derivatives generated in side reaction was proved and the structural influence of the length of the aliphatic residue on the antioxidant effectiveness of the sulfides derived from the corresponding hydroxyalkylphenols was examined.

  DOI：

  10.1134/s1070363210100208

文献信息

• Alpha-substituted carboxylic acid derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030069294A1

  公开（公告）日：2003-04-10

  The &agr;-substituted carboxylic acid derivatives having the formula (I): 1 wherein R 1 is an alkyl group, etc., R 2 is a hydrogen atom, etc., R 3 is a hydrogen atom, etc., A is ═CH-group, etc., B is an oxygen atom, etc., W 1 is a C 1 -C 8 alkylene group, W 2 is a single bond or a C 1 -C 8 alkylene group, X is a hydrogen atom, etc., Y is an oxygen atom, etc., and Z 1 is an alkoxy group, etc., and pharmacologically acceptable salts, esters and amides thereof are useful for treatment and/or prevention of diabetes mellitus, impaired glucose tolerance, gestational diabetes mellitus, or the like. Some of the derivatives of the formula (I) are novel compounds.

  具有如下式(I)的α-取代羧酸衍生物，其中R1是烷基基团，R2是氢原子，R3是氢原子，A是═CH-基团，B是氧原子，W1是C1-C8烷基基团，W2是单键或C1-C8烷基基团，X是氢原子，Y是氧原子，Z1是烷氧基团，其药理学上可接受的盐、酯和酰胺对于治疗和/或预防糖尿病、糖耐量受损、妊娠期糖尿病等疾病是有用的。其中一些具有如上式(I)的衍生物是新化合物。
• Process for producing phosphite
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20040225145A1

  公开（公告）日：2004-11-11

  There is provided a process for producing a phosphite of the formula (I): 1 wherein R 1 , R 2 , R 4 and R 5 each independently represent a hydrogen atom, a C1-8 alkyl group, a C5-8 cycloalkyl group, a C6-12 alkylcycloalkyl group, a C7-12 aralkyl group or a phenyl group or a phenyl group substituted with an alkyl or an alkoxy group; R 3 represents a hydrogen atom or a C1-8 alkyl group; A represents a C2-8 alkylene group or a *—C(═O)— or *—C(═O)—R 7 — group in which R 7 represents a C1-8 alkylene group, and the bond marked with* is the bond connected with the oxygen atom; and one of Y and Z represents a hydroxyl group, a C1-8 alkoxy group or a C7-12 aralkyloxy group and the other one represents a hydrogen atom or a C1-8 alkyl group.

  提供了一种制备式(I)磷酸酯的方法，其中R1、R2、R4和R5各自独立地表示氢原子、C1-8烷基、C5-8环烷基、C6-12烷基环烷基、C7-12芳基烷基或苯基或被烷基或烷氧基取代的苯基；R3表示氢原子或C1-8烷基；A表示C2-8烷基或*—C(═O)—或*—C(═O)—R7—，其中R7表示C1-8烷基，标记为*的键连接着氧原子；Y和Z中的一个表示羟基、C1-8烷氧基或C7-12芳基烷氧基，另一个表示氢原子或C1-8烷基。
• Medicinal compositions containing diuretic and insulin resistance-improving agent
  申请人：Takaoka Masaya

  公开号：US20050288339A1

  公开（公告）日：2005-12-29

  The present invention relates to a pharmaceutical composition comprising an insulin sensitizer and a diuretic which can prevent or treat side effects such as edema, cardiac enlargement, body fluid retension or hydrothorax caused by administration of an insulin sensitizer.

  本发明涉及一种药物组合物，包括胰岛素增敏剂和利尿剂，可以预防或治疗由于胰岛素增敏剂的使用引起的水肿、心脏肥大、体液潴留或胸水等副作用。
• Alkylation of 2,6-di-tert.-alkylphenols with alkanediols
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP0028200A1

  公开（公告）日：1981-05-06

  There is a process disclosed for alkylating the nucleus of a phenol, said process comprising reacting an α,ω alkanediol containing from 3 to 8 carbon atoms with a phenol having an unsubstituted nuclear position para to the phenolic hydroxyl group; said phenol being selected from the group of alkylated phenols having tertiary alkyl groups of 4 to 8 carbon atoms in both positions ortho to the phenolic hydroxyl group, in the presence of an alkali metal hydroxide or alkoxide or alkali metal at a temperature from 200 to 300° C while continuously removing the water by-product as it forms and obtaining as a product said phenol having a primary hydroxy terminated alkyl group of 3 to 8 carbon atoms in said para position.

  公开了一种使苯酚核烷基化的工艺，该工艺包括在碱金属氢氧化物或碱金属氧化物或碱金属存在下，在 200 至 300 摄氏度的温度下，使含有 3 至 8 个碳原子的 α、ω 烷二醇与具有与酚羟基对位的未取代核位置的苯酚反应；所述苯酚选自在与酚羟基正交的两个位置上具有 4 至 8 个碳原子的叔烷基的烷基化苯酚组，同时不断除去形成的水副产物，并得到在所述对位位置上具有 3 至 8 个碳原子的伯羟基末端烷基的所述苯酚作为产物。
• Phosphites, process for producing the same and their use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0823435A2

  公开（公告）日：1998-02-11

  A phosphite of formula (I): wherein R1, R2, R4 and R5 represent hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcycloalkyl group, an aralkyl group or a phenyl group; R3 represents hydrogen atom or an alkyl group; X represents a direct bond, sulfur atom, or a -CHR6- group in which R6 represents hydrogen atom, an alkyl group or a cycloalkyl group; A represents an alkylene group having 2 to 8 carbon atoms or a *-COR7-group in which R7 represents a direct bond or an alkylene group, and * indicates the bond to the oxygen; and one of Y and Z represents a hydroxyl group, an alkoxy group or an aralkyloxy group and the other one represents hydrogen atom or an alkyl group, is suitably used as a stabilizer for an organic material.

  式(I)的亚磷酸酯： 其中 R1、R2、R4 和 R5 代表氢原子、烷基、环烷基、烷基环烷基、芳基或苯基；R3 代表氢原子或烷基；X 代表直接键、硫原子或-CHR6-基团，其中 R6 代表氢原子、烷基或环烷基；A 代表具有 2 至 8 个碳原子的亚烷基或 *-COR7- 基团，其中 R7 代表直接键或亚烷基，* 表示与氧的键合；Y 和 Z 中的一个代表羟基、烷氧基或芳氧基，另一个代表氢原子或烷基。