N-(2,3-二氢-1H-茚-4-基)-4,5-二氢-1H-咪唑-2-胺盐酸盐 | 40507-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: N-(2,3-二氢-1H-茚-4-基)-4,5-二氢-1H-咪唑-2-胺盐酸盐
• 英文名称: Indanazolin-hydrochlorid
• 英文别名: N-(2,3-dihydro-1H-inden-4-yl)-4,5-dihydro-1H-imidazol-2-amine;hydron;chloride
• CAS: 40507-80-0
• 化学式: C₁₂H₁₅N₃*ClH
• 分子量: 237.732
• InChiKey: GZVYIVIJAOMGJT-UHFFFAOYSA-N

物化性质

• 熔点：
  182-184°

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  36.4
• 氢给体数：
  3
• 氢受体数：
  1

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  N-(2,3-二氢-1H-茚-4-基)-4,5-二氢-1H-咪唑-2-胺盐酸盐 以 水 为溶剂， 生成 4-氨基茚满
  参考文献：
  名称：

  Dechow; Lammerhirt; Pich, Arzneimittel-Forschung/Drug Research, 1980, vol. 30, # 10, p. 1738 - 1746

  摘要：

  DOI：
• 作为产物：
  描述：

  N-4-Indanyl-S-methyl-isothioharnstoff 、 ethylene diamine mono-p-toluenesulfonic acid salt 在 盐酸 作用下， 以 various solvent(s) 为溶剂， 反应 5.0h， 以76%的产率得到N-(2,3-二氢-1H-茚-4-基)-4,5-二氢-1H-咪唑-2-胺盐酸盐
  参考文献：
  名称：

  May, Arzneimittel-Forschung/Drug Research, 1980, vol. 30, # 10, p. 1733 - 1737

  摘要：

  DOI：

文献信息

• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
• METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY
  申请人：West Michael D.

  公开号：US20100184033A1

  公开（公告）日：2010-07-22

  Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.
• US7790905B2
  申请人：——

  公开号：US7790905B2

  公开（公告）日：2010-09-07