(R)-2-Acetoxy-4-hydroxy-butyric acid benzyl ester | 211860-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-Acetoxy-4-hydroxy-butyric acid benzyl ester
• 英文别名: benzyl (2R)-2-acetyloxy-4-hydroxybutanoate
• CAS: 211860-58-1
• 化学式: C₁₃H₁₆O₅
• 分子量: 252.267
• InChiKey: LBMHVRSORLGUFX-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-2-Acetoxy-4-hydroxy-butyric acid benzyl ester 在 palladium on activated charcoal 吡啶 、 氢气 作用下， 以 乙醇 为溶剂， 反应 44.0h， 生成 2,4-di-O-acetyl-3-deoxy-L-glycero-tetronic acid
  参考文献：
  名称：

  Synthesis of terminal disaccharide elements corresponding to the Ogawa and Inaba antigenic determinant from Vibrio cholerae O1

  摘要：

  Vibrio cholerae 01 LPS terminal mono- and disaccharide elements were synthesized by reduction of the azido group in several 4-amino-4,6-dideoxy-D-mannose mono- and disaccharide derivatives, followed by coupling with 2,4-di-O-acetyl-3-deoxy-L-glycero-tetronic acid in the presence of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline. This compound represents a useful model in order to elucidate the size of the epitopes which define Ogawa and Inaba serotypes from Vibrio cholerae 01. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(97)10052-0
• 作为产物：
  描述：

  (S)-3-乙酰氧基二氢-2,5-呋喃二酮 O-乙酰基-L-苹果酸酐 在 硼烷四氢呋喃络合物 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成 (R)-2-Acetoxy-4-hydroxy-butyric acid benzyl ester
  参考文献：
  名称：

  Synthesis of terminal disaccharide elements corresponding to the Ogawa and Inaba antigenic determinant from Vibrio cholerae O1

  摘要：

  Vibrio cholerae 01 LPS terminal mono- and disaccharide elements were synthesized by reduction of the azido group in several 4-amino-4,6-dideoxy-D-mannose mono- and disaccharide derivatives, followed by coupling with 2,4-di-O-acetyl-3-deoxy-L-glycero-tetronic acid in the presence of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline. This compound represents a useful model in order to elucidate the size of the epitopes which define Ogawa and Inaba serotypes from Vibrio cholerae 01. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(97)10052-0

文献信息

• METHOD FOR PREPARING COAGULATION FACTOR XIA INHIBITOR AND INTERMEDIATE THEREOF
  申请人：JIANGSU HENGRUI MEDICINE CO., LTD.

  公开号：US20210292279A1

  公开（公告）日：2021-09-23

  The present disclosure involves a method for preparing a coagulation factor XIa inhibitor and an intermediate thereof. Specifically, the present disclosure involves a method for preparing an oxypyridine amide derivative. The method has the advantages of high yield, good product purity, and mild reaction conditions.

  本公开涉及一种制备凝血因子XIa抑制剂及其中间体的方法。具体而言，本公开涉及一种制备氧吡啶酰胺衍生物的方法。该方法具有高产率、良好的产品纯度和温和的反应条件的优点。
• [EN] METHOD FOR PREPARING COAGULATION FACTOR XIA INHIBITOR AND INTERMEDIATE THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN INHIBITEUR DU FACTEUR XIA DE COAGULATION ET INTERMÉDIAIRE DE CELUI-CI<br/>[ZH] 一种凝血因子XIa抑制剂及其中间体的制备方法
  申请人：JIANGSU HENGRUI MEDICINE CO

  公开号：WO2020015698A1

  公开（公告）日：2020-01-23

  本公开涉及一种凝血因子XIa抑制剂及其中间体的制备方法。具体而言，本公开涉及一种氧代吡啶酰胺类衍生物的制备方法，该方法收率高、产物纯度好、反应条件温和。