3-[2-(4-Methylpyridin-2-yl)pyridin-4-yl]propane-1-thiol | 483966-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-[2-(4-Methylpyridin-2-yl)pyridin-4-yl]propane-1-thiol
• CAS: 483966-09-2
• 化学式: C₁₄H₁₆N₂S
• 分子量: 244.36
• InChiKey: FISPQFDENFQGJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  26.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[2-(4-Methylpyridin-2-yl)pyridin-4-yl]propane-1-thiol 、 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  10.1021/jp064878

  摘要：

  DOI：

  10.1021/jp064878
• 作为产物：
  描述：

  4-(3-bromopropyl)-4'-methyl-2,2'-bipyridine 在 一水合肼 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 3-[2-(4-Methylpyridin-2-yl)pyridin-4-yl]propane-1-thiol
  参考文献：
  名称：

  钌联吡啶配合物的合成与表面组装

  摘要：

  从黄原酸盐官能化的联吡啶开始制备二硫化物官能化的联吡啶和相应的硫醇衍生物。肼还原黄原酸盐导致形成硫醇和二硫化物官能化联吡啶的混合物，可以通过尺寸排阻色谱法分离。联吡啶单元的螯合特性用于制备荧光杂配钌配合物，而分子另一端的硫醇或二硫化物基团用于将单个配体以及形成的配合物锚定到固体基质上。使用扫描隧道显微镜观察这些物质在平坦的金 (111) 基板上的组装情况。

  DOI：

  10.1071/ch07085

文献信息

• [EN] USE OF METAL-ION CHELATES IN VALIDATING BIOLOGICAL MOLECULES AS DRUG TARGETS IN TEST ANIMAL MODELS<br/>[FR] UTILISATION DE CHELATES A IONS METALLIQUES DANS LA VALIDATION DE MOLECULES BIOLOGIQUES UTILISEES COMME CIBLES MEDICAMENTEUSES DANS DES MODELES ANIMAUX EXPERIMENTAUX
  申请人：7TM PHARMA AS

  公开号：WO2003003009A1

  公开（公告）日：2003-01-09

  Use of chemical compounds or selections of chemical compounds (libraries) of the general Formula (I): for in vivo methods for testing or validating the physiological importance and/or the therapeutic or pharmacological potential of biological target molecules, notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biological target molecule with, notably, a silent, engineered metal-ion site. Use of specific metal-ion binding sites of a generic nature in specific biological target molecules such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. Chemical compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behaviour of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal-ion chelates). In order to improve the efficacy of the metal-ion chelates impact on the biological target molecule after administration of the metal-ion chelate in vivo to a test animal it is advantageous e.g. to increase the time period during which the metal-ion chelate is in the circulatory system and/or localised at the target. Metal-ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed.
• Synthesis and Surface Assembly of Ruthenium Bipyridine Complexes
  作者：Veronica Marin、Daan Wouters、Stephanie Hoeppener、Elisabeth Holder、Ulrich S. Schubert

  DOI：10.1071/ch07085

  日期：——

  bipyridine and the corresponding thiol derivative were prepared starting from xanthogenate-functionalized bipyridine. The reduction of the xanthogenate by hydrazine led to the formation of a mixture of thiol and disulfide-functionalized bipyridines that could be separated by size exclusion chromatography. The chelating properties of the bipyridine units were used to prepare fluorescent heteroleptic ruthenium

  从黄原酸盐官能化的联吡啶开始制备二硫化物官能化的联吡啶和相应的硫醇衍生物。肼还原黄原酸盐导致形成硫醇和二硫化物官能化联吡啶的混合物，可以通过尺寸排阻色谱法分离。联吡啶单元的螯合特性用于制备荧光杂配钌配合物，而分子另一端的硫醇或二硫化物基团用于将单个配体以及形成的配合物锚定到固体基质上。使用扫描隧道显微镜观察这些物质在平坦的金 (111) 基板上的组装情况。
• 10.1021/jp064878
  作者：Pramod、Sudeep、Thomas, K. George、Kamat, Prashant V.

  DOI：10.1021/jp064878

  日期：——