{4-[4-(4-Benzyloxy-3,5-dimethoxy-benzyloxy)-3,5-dimethoxy-benzyloxy]-3,5-dimethoxy-phenyl}-methanol | 670275-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {4-[4-(4-Benzyloxy-3,5-dimethoxy-benzyloxy)-3,5-dimethoxy-benzyloxy]-3,5-dimethoxy-phenyl}-methanol
• 英文别名: [4-[[4-[(3,5-Dimethoxy-4-phenylmethoxyphenyl)methoxy]-3,5-dimethoxyphenyl]methoxy]-3,5-dimethoxyphenyl]methanol
• CAS: 670275-24-8
• 化学式: C₃₄H₃₈O₁₀
• 分子量: 606.67
• InChiKey: POBGXRSHOMHSSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  丁香醛 、 {4-[4-(4-Benzyloxy-3,5-dimethoxy-benzyloxy)-3,5-dimethoxy-benzyloxy]-3,5-dimethoxy-phenyl}-methanol 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成 4-{4-[4-(4-Benzyloxy-3,5-dimethoxy-benzyloxy)-3,5-dimethoxy-benzyloxy]-3,5-dimethoxy-benzyloxy}-3,5-dimethoxy-benzaldehyde
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d
• 作为产物：
  描述：

  丁香醛 在 sodium tetrahydroborate 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 {4-[4-(4-Benzyloxy-3,5-dimethoxy-benzyloxy)-3,5-dimethoxy-benzyloxy]-3,5-dimethoxy-phenyl}-methanol
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d

文献信息

• Synthesis of Ether Oligomers
  作者：Olivier Renaudet、Jean-Louis Reymond

  DOI：10.1021/ol036300d

  日期：2004.2.1

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.