(7Z,10Z)-Hexadeca-7,10-dienoic acid (R)-1-hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl ester | 171743-44-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (7Z,10Z)-Hexadeca-7,10-dienoic acid (R)-1-hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl ester
• CAS: 171743-44-5
• 化学式: C₂₅H₄₄O₉
• 分子量: 488.619
• InChiKey: URJTWSVJGAUSNF-NQNUALNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  34.0
• 可旋转键数：
  18.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  145.91
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (7Z,10Z)-Hexadeca-7,10-dienoic acid (R)-1-hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以1.4 mg的产率得到(7Z,10Z)-hexadecadienoic acid methyl ester
  参考文献：
  名称：

  Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris

  摘要：

  Two new monogalactosyl diacylglycerols were isolated from the freshwater green alga, Chlorella vulgaris, as anti-tumour promoters, together with three monogalactosyl diacylglycerols and two digalactosyl diacylglycerols. The new monogalactosyl diacylglycerol containing (7Z,10Z)-hexadecadienoic acid showed a more potent inhibitory effect toward tumour promotion than the other glycerolipids isolated.

  DOI：

  10.1016/0031-9422(95)00458-j
• 作为产物：
  描述：

  (2S)-1-O-(7Z,10Z,13Z)-hexadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O-β-D-galactopyranosyl-sn-glycerol 在 boric acid-borax buffer 、 Lipase type XI 、 Triton X-100 作用下， 反应 1.0h， 生成 7,10,13顺-十六碳三烯酸 、 (7Z,10Z)-Hexadeca-7,10-dienoic acid (R)-1-hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl ester
  参考文献：
  名称：

  Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris

  摘要：

  Two new monogalactosyl diacylglycerols were isolated from the freshwater green alga, Chlorella vulgaris, as anti-tumour promoters, together with three monogalactosyl diacylglycerols and two digalactosyl diacylglycerols. The new monogalactosyl diacylglycerol containing (7Z,10Z)-hexadecadienoic acid showed a more potent inhibitory effect toward tumour promotion than the other glycerolipids isolated.

  DOI：

  10.1016/0031-9422(95)00458-j