(Z)-2-Ethyl-4-methyl-2-pentenoic acid | 77124-24-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2-Ethyl-4-methyl-2-pentenoic acid
• 英文别名: (Z)-2-ethyl-4-methylpent-2-enoic acid
• CAS: 77124-24-4
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: HJJSESWQNLXZNF-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-2-Ethyl-4-methyl-2-pentenoic acid 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (E)-2-Ethyl-4-methyl-pent-2-enoyl chloride
  参考文献：
  名称：

  Regioselectivity of rhodium(II)-catalyzed decomposition of 1-alkyl-1-(diazoacetyl)alkenes. Synthesis of 2-alkyl-2-cyclopentenones and 2-alkylidenecyclopentanones

  摘要：

  The synthesis of 1-alkyl-1-(diazoacetyl)alkenes and their dirhodium tetraacetate catalyzed transformation into 2-cyclopentenones and 2-alkylidenecyclopentanones are described. The competitive, intramolecular carbon-hydrogen insertion at two gamma-centers is discussed.

  DOI：

  10.1021/jo00025a022
• 作为产物：
  描述：

  Ethyl (Z)-2-ethyl-4-methyl-2-pentenoate 在 氢氧化钾 作用下， 反应 8.0h， 以84%的产率得到(Z)-2-Ethyl-4-methyl-2-pentenoic acid
  参考文献：
  名称：

  Regioselectivity of rhodium(II)-catalyzed decomposition of 1-alkyl-1-(diazoacetyl)alkenes. Synthesis of 2-alkyl-2-cyclopentenones and 2-alkylidenecyclopentanones

  摘要：

  The synthesis of 1-alkyl-1-(diazoacetyl)alkenes and their dirhodium tetraacetate catalyzed transformation into 2-cyclopentenones and 2-alkylidenecyclopentanones are described. The competitive, intramolecular carbon-hydrogen insertion at two gamma-centers is discussed.

  DOI：

  10.1021/jo00025a022

文献信息

• FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
  申请人：Chiu Daniel T.

  公开号：US20120282632A1

  公开（公告）日：2012-11-08

  The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

  本发明提供了功能化的色团聚合物点，包括疏水性核心和亲水性帽子，以及其生物共轭物。同时提供了改进的制备功能化色团聚合物点的方法。还揭示了用于体内成像和分子标记的方法。
• Pyridopyrimidine derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0608565A1

  公开（公告）日：1994-08-03

  The new pyridopyrimidine derivative of the formula (A), wherein n denotes an integer of 0 to 3, Q stands for -(CH₂) m - ( m denotes an integer of 0 to 2), -O-, -S(O)p-( p denotes an integer of 0 to 2 ) or -N-, and R¹ to R⁶ stand for substituents, or its salt is described. Preparation of them and use to endothelin receptor antagonistic agent are exemplified. An endothelin receptor antagonist consisting of said compound is effective as therapeutic composition of acute renal insufficiency, myocardial infarction, hypertension, cerebral infarction, angina pectoris, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction occuring during operation or transplantation of organs.

  描述了式(A)的新吡啶嘧啶衍生物，其中n表示0至3的整数，Q表示-(CH₂)m-（m表示0至2的整数）、-O-、-S(O)p-（p表示0至2的整数）或-N-，R¹至R⁶表示取代基，或其盐。举例说明了它们的制备及其在内皮素受体拮抗剂中的应用。由所述化合物组成的内皮素受体拮抗剂作为急性肾功能不全、心肌梗塞、高血压、脑梗塞、心绞痛、动脉硬化、肝病、肺动脉高压、支气管哮喘、器官手术或移植过程中发生的器官功能减退的治疗成分是有效的。
• CHROMOPHORIC POLYMER DOTS
  申请人：University of Washington through its Center for Commercialization

  公开号：EP3434642A1

  公开（公告）日：2019-01-30

  The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

  除其他方面外，本发明还提供了稳定的发色性纳米粒子。在某些实施例中，本发明提供的色素纳米粒子被合理地用预定数量的官能团官能化。在某些实施例中，本文提供的稳定的色素纳米粒子用低密度的官能团修饰。在另一些实施例中，本文提供的发色纳米粒子与一种或多种分子共轭。本文还提供了制作合理官能化的色素纳米粒子的方法。
• FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
  申请人：University Of Washington Center For Commercialization

  公开号：EP3483610A1

  公开（公告）日：2019-05-15

  The present invention provides, among other aspects, functionalized chromophoric polymer dots, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

  除其他方面外，本发明还提供了功能化发色性聚合物点及其生物共轭物。本发明还提供了制备功能化发色性聚合物点的改进方法。本发明还公开了体内成像和分子标记的方法。
• ENCODED CHROMOPHORIC POLYMER PARTICLES
  申请人：University of Washington through its Center for Commercialization

  公开号：EP3521399A1

  公开（公告）日：2019-08-07

  The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

  本公开提供了可对分析物进行光学和/或生物分子编码的编码发色性聚合物颗粒。本公开还提供了包含多个编码发色性聚合物颗粒的悬浮液。本公开还提供了使用编码发色性聚合物颗粒的方法以及使用编码发色性聚合物颗粒进行多重分析的系统。