顺-1,3-双(氨甲基)环己烷 | 10340-00-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 顺-1,3-双(氨甲基)环己烷
• 中文别名: 顺-1,3-双(氨基甲基)环己烷
• 英文名称: 1,3-bis(aminomethyl)cyclohexane
• 英文别名: 1,3-cis-bis(aminomethyl)cyclohexane；cis-1,3-Bis-(aminomethyl)-cyclohexan；cis-1,3-Cyclohexan-bis-methylamin；cis-1,3-Bis(aminomethyl)cyclohexane；[(1R,3S)-3-(aminomethyl)cyclohexyl]methanamine
• CAS: 10340-00-8
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: QLBRROYTTDFLDX-OCAPTIKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,4-三羟基苯甲醛 、 顺-1,3-双(氨甲基)环己烷 以 甲醇 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Sarojini; Ramachandraiah, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1996, vol. 35, # 11, p. 940 - 945

  摘要：

  DOI：
• 作为产物：
  描述：

  3-azabicyclo[3.3.1]nonane 在 氨 、 氢气 作用下， 以 叔丁醇 为溶剂， 140.0 ℃ 、11.06 MPa 条件下， 反应 23.0h， 生成 顺-1,3-双(氨甲基)环己烷
  参考文献：
  名称：

  A PROCESS FOR THE CONVERSION OF ALIPHATIC CYCLIC AMINES TO ALIPHATIC DIAMINES

  摘要：

  公开号：

  EP2459513B1

文献信息

• COMPOSITIONS COMPRISING A POLYMERIC NETWORK
  申请人：UNIVERSITEIT GENT

  公开号：US20170327625A1

  公开（公告）日：2017-11-16

  The present invention relates to a composition comprising a polymeric network having at least one unit of formula (I), (II), and/or (III); (I) (II) (III) wherein said composition is obtained by contacting at least one compound A comprising at least two functions selected from the group of function of formula X—C(═O)—CHR 1 —C(═O)—R 2 , —C(═O)—C—R 2 ; or —C(═O)—CR 1 ═CR 2 —NR 4 R 5 ; wherein at least 25% by weight of compounds A have a functionality ≦5, with % by weight relative to the total weight of compounds A; with at least one compound B comprising at least one NH 2 , or NH 3 + groups; wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , L 1 and L 2 have the same meaning as that defined in the claims. The present invention also relates to a compound comprising at least two units and at most 5 units of formula (I), (II), and/or (III); wherein R 1 , R 2 , R 3 , X, L 1 and L 2 have the same meaning as that defined in the claims. The present invention also relates to processes for preparing said composition and said compounds, to material, articles, and polymers comprising or using said compositions and compounds, and the use thereof.

  本发明涉及一种组合物，其包括至少一种具有式(I)、(II)和/或(III)的聚合网络单元；其中所述组合物是通过接触至少一种化合物A而获得的，所述化合物A包括至少两种选自以下功能组的功能：X—C(═O)—CHR1—C(═O)—R2，—C(═O)—C—R2；或—C(═O)—CR1═CR2—NR4R5；其中化合物A的至少25%的重量具有功能性≦5，以重量百分比相对于化合物A的总重量计算；以及至少一种包括至少一个NH2或NH3+基团的化合物B；其中X、R1、R2、R3、R4、R5、L1和L2的含义与权利要求书中定义的含义相同。本发明还涉及一种化合物，其包括至少两个单元和最多5个式(I)、(II)和/或(III)的单元；其中R1、R2、R3、X、L1和L2的含义与权利要求书中定义的含义相同。本发明还涉及制备所述组合物和所述化合物的方法，以及包括或使用所述组合物和化合物的材料、物品和聚合物，以及其用途。
• Macrocyclic Spiro Pyrimidine Derivatives
  申请人：Liu Huaqing

  公开号：US20090233904A1

  公开（公告）日：2009-09-17

  Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

  本文描述了大环螺环嘧啶化合物、包含这种化合物的组合物、制备这些化合物的方法，以及利用这种化合物和组合物治疗和预防疾病、病况和障碍的方法。
• Non-peptide somatostatin receptor ligands
  申请人：——

  公开号：US20030191134A1

  公开（公告）日：2003-10-09

  Non-peptide somatostatin receptor ligands with conformationally restricted side chains exhibiting high binding affinity toward somatostatin receptors are provided. The compounds exhibit a high selectivity and act as agonists at human subtype 2 somatostatin receptors. The compounds are long acting for advantageous use as medicaments in peripheral diseases where somatostatinergic therapy is indicated. Furthermore, many of the compounds are lipophilic and are particularly useful for treating central nervous system and ophthalmic diseases where penetration of the blood brain and blood retinal barriers is required. It is a further object to describe the preferred stereoisomers of these somatostatin agonists and processes for their preparation. Further objects will become apparent from reading the following description.

  提供了具有构象限制侧链的非肽生长抑素受体配体，其表现出高结合亲和力，适用于生长抑素受体。这些化合物表现出高选择性并作为人类亚型2生长抑素受体的激动剂。这些化合物具有长效作用，可作为药物用于需要生长抑素治疗的周围疾病。此外，许多化合物是亲脂性的，并且对于治疗需要穿过血脑屏障和血视网膜屏障的中枢神经系统和眼科疾病特别有用。进一步描述了这些生长抑素激动剂的优选立体异构体和其制备过程。阅读以下描述后，将出现更多的目标。
• METHOD FOR PRODUCING BIS(AMINOMETHYL)CYCLOHEXANES
  申请人：Yoshimura Naritoshi

  公开号：US20130197269A1

  公开（公告）日：2013-08-01

  A method for producing bis(aminomethyl)cyclohexanes includes a nuclear hydrogenation step of producing hydrogenated phthalic acids or phthalic acid derivatives by nuclear hydrogenation of phthalic acids or phthalic acid derivatives of at least one selected from the group consisting of phthalic acids, phthalic acid esters, and phthalic acid amides; a cyanation step of treating the hydrogenated phthalic acids or phthalic acid derivatives obtained in the nuclear hydrogenation step with ammonia, thereby producing dicyanocyclohexanes; and an aminomethylation step of treating the dicyanocyclohexanes obtained in the cyanation step with hydrogen, thereby producing bis(aminomethyl)cyclohexanes. In the cyanation step, metal oxide is used as a catalyst, and the obtained dicyanocyclohexanes have a metal content of 3000 ppm or less.

  一种生产双(氨甲基)环己烷的方法，包括以下步骤：核氢化步骤，通过对邻苯二甲酸或邻苯二甲酸衍生物进行核氢化，得到氢化的邻苯二甲酸或邻苯二甲酸衍生物，所述邻苯二甲酸或邻苯二甲酸衍生物至少选自邻苯二甲酸、邻苯二甲酸酯和邻苯二甲酸酰胺组成的群体；青化步骤，将在核氢化步骤中获得的氢化邻苯二甲酸或邻苯二甲酸衍生物与氨处理，从而产生二氰基环己烷；氨甲基化步骤，将在青化步骤中获得的二氰基环己烷与氢处理，从而产生双(氨甲基)环己烷。在青化步骤中，使用金属氧化物作为催化剂，所获得的二氰基环己烷的金属含量为3000 ppm或更低。
• Polyurethane dispersion and articles prepared therefrom
  申请人：Argyropoulos N. John

  公开号：US20070265388A1

  公开（公告）日：2007-11-15

  The present invention is to a polyurethane dispersion and products produced therefrom wherein the dispersion contains a polyurethane prepolymer produced from the a reaction of an excess of a polyisocyante with an isocyanate reactive molecule wherein the polyisocyante is a bis(isocyanatomethyl)cyclohexane. Preferably the isocyanate comprises (i) trans-1,4-bis(isocyanatomethyl)cyclohexane or (ii) an isomeric mixture of two or more of cis-1,3-bis(isocyanatomethyl)cyclohexane, trans-1,3-bis(isocyanatomethyl)cyclohexane, cis-1,4-bis(isocyanatomethyl)cyclohexane and trans-1,4-bis(isocyanatomethyl)cyclohexane, with the proviso said isomeric mixture comprises at least about 5 weight percent of said trans-1,4-bis(isocyanatomethyl)cyclohexane.

  本发明涉及一种聚氨酯分散液及其制备的产品，其中该分散液含有由多异氰酸酯过量与异氰酸反应生成的聚氨酯预聚物，所述多异氰酸酯是双(异氰酸甲基)环己烷。优选的异氰酸酯包括(i) 反-1,4-双(异氰酸甲基)环己烷或(ii) 由顺-1,3-双(异氰酸甲基)环己烷、反-1,3-双(异氰酸甲基)环己烷、顺-1,4-双(异氰酸甲基)环己烷和反-1,4-双(异氰酸甲基)环己烷中的两种或多种异构体混合而成，但至少包括约5重量％的反-1,4-双(异氰酸甲基)环己烷。