2-(N-Benzylidenamino)-phenylessigsaeure | 875656-65-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(N-Benzylidenamino)-phenylessigsaeure
• CAS: 875656-65-8
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: YDMVCHHYLLLLAF-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.66
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  allyl N-benzylidene(phenyl)glycinate 在 碘 、 二甲基亚砜 作用下， 反应 0.5h， 以65%的产率得到2-(N-Benzylidenamino)-phenylessigsaeure
  参考文献：
  名称：

  Dimethylsulfoxide–iodine catalysed deprotection of allyl carboxylic esters

  摘要：

  A convenient method for deprotection of allyl carboxylic esters has been developed by using the inexpensive and environmentally friendly reagent dimethylsulfoxide-iodine. A variety of carboxylic esters were deprotected to the carboxylic acids. This method is more efficient and operationally simple in comparison to methods using transition metal complexes. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.130

文献信息

• [EN] BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS<br/>[FR] DÉRIVÉS BIARYLE EN TANT QU'INHIBITEURS D'INTERACTION PROTÉINE-PROTÉINE YAP/TAZ-TEAD
  申请人：NOVARTIS AG

  公开号：WO2021186324A1

  公开（公告）日：2021-09-23

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

  本发明提供了化合物(I)或其药学上可接受的盐；(I)制造所述化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合物和包括所述化合物的药物组合。
• BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS
  申请人：Novartis AG

  公开号：US20210299100A1

  公开（公告）日：2021-09-30

  The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.