butyl (E)-3-[5-[4-(trifluoromethyl)phenyl]thiophen-2-yl]prop-2-enoate | 1160456-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl (E)-3-[5-[4-(trifluoromethyl)phenyl]thiophen-2-yl]prop-2-enoate
• CAS: 1160456-99-4
• 化学式: C₁₈H₁₇F₃O₂S
• 分子量: 354.393
• InChiKey: OLUYRYQEIXOLEW-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙烯酸丁酯 、 2-(4-(trifluoromethyl)phenyl)thiophene 在 吡啶 、 silver(I) acetate 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以76%的产率得到butyl (E)-3-[5-[4-(trifluoromethyl)phenyl]thiophen-2-yl]prop-2-enoate
  参考文献：
  名称：

  Palladium-catalyzed alkenation of thiophenes and furans by regioselective C–H bond functionalization

  摘要：

  A palladium-catalyzed direct alkenation of thiophenes and furans has been developed in the presence of AgOAc and pyridine. A variety of olefinic substrates such as acrylates, acrylamides, and acrylonitrile can perform the direct oxidative coupling reactions with various thiophenes and furans to give the mono-alkenylated products in good yields. In most cases, the (E)-isomers were isolated as the major products. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.124

文献信息

• Palladium-catalyzed alkenation of thiophenes and furans by regioselective C–H bond functionalization
  作者：Jinlong Zhao、Lehao Huang、Kai Cheng、Yuhong Zhang

  DOI：10.1016/j.tetlet.2009.03.124

  日期：2009.6

  A palladium-catalyzed direct alkenation of thiophenes and furans has been developed in the presence of AgOAc and pyridine. A variety of olefinic substrates such as acrylates, acrylamides, and acrylonitrile can perform the direct oxidative coupling reactions with various thiophenes and furans to give the mono-alkenylated products in good yields. In most cases, the (E)-isomers were isolated as the major products. (C) 2009 Elsevier Ltd. All rights reserved.