2-Chlor-3-brom-1-nitro-5-methyl-benzol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chlor-3-brom-1-nitro-5-methyl-benzol
• 英文别名: 5-Bromo-2-chloro-1-methyl-3-nitrobenzene
• 化学式: C₇H₅BrClNO₂
• 分子量: 250.479
• InChiKey: APKDWSJHWVOZGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Chlor-3-brom-1-nitro-5-methyl-benzol 、 4-溴苯磺酰胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.2h， 以92%的产率得到4-bromo-N-(4-bromo-2-methyl-6-nitrophenyl)benzenesulfonamide
  参考文献：
  名称：

  A microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium

  摘要：

  A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation. A series of pyrabactin analogues containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 3ae could enhance POD activity in response to heavy metal stress. (C) 2019 The Author(s). Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2019.01.041

文献信息

• A microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium
  作者：Zhi-You Huang、Min Liu、Yi-Jun Mao、Yu-De Chen、Yan-Ping Wang、Chong Liu

  DOI：10.1016/j.tetlet.2019.01.041

  日期：2019.2

  A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation. A series of pyrabactin analogues containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 3ae could enhance POD activity in response to heavy metal stress. (C) 2019 The Author(s). Published by Elsevier Ltd.