4-tosyl-2-benzylsulfonyl-5-chloro-1,3-thiazole | 557773-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tosyl-2-benzylsulfonyl-5-chloro-1,3-thiazole
• 英文别名: 2-(Benzylsulfonyl)-5-chloro-4-tosylthiazole；2-benzylsulfonyl-5-chloro-4-(4-methylphenyl)sulfonyl-1,3-thiazole
• CAS: 557773-74-7
• 化学式: C₁₇H₁₄ClNO₄S₃
• 分子量: 427.953
• InChiKey: FWSUPOBPIYOYGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-tosyl-2-benzylsulfonyl-5-chloro-1,3-thiazole 在 三乙胺 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 4.0h， 生成 5-morpholino-4-tosyl-2-p-tolylthio-1,3-thiazole
  参考文献：
  名称：

  摘要：

  Treatment of 1-tosyl-2,2-dichloroethenyl isothiocyanate with alcohols, thiols, primary and secondary amines, hydrazine and its derivatives, and phosphonium ylides results in addition of the O-, S-, N-, or C-nucleophilic center to the isothiocyanate, group, followed by cyclocondensation with elimination of hydrogen chloride and formation of the corresponding 2-functionally substituted 4-tosyl-5-chloro-1,3-thiazoles. Further transformations of these compounds were studied, and a series of previously unknown types of 3-functionally substituted 1,3-thiazole derivatives were prepared.

  DOI：

  10.1023/a:1023337112138
• 作为产物：
  描述：

  4-tosyl-2-p-tolylsulfonyl-5-chloro-1,3-thiazole 在 双氧水 、 溶剂黄146 、 三乙胺 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 4-tosyl-2-benzylsulfonyl-5-chloro-1,3-thiazole
  参考文献：
  名称：

  摘要：

  Treatment of 1-tosyl-2,2-dichloroethenyl isothiocyanate with alcohols, thiols, primary and secondary amines, hydrazine and its derivatives, and phosphonium ylides results in addition of the O-, S-, N-, or C-nucleophilic center to the isothiocyanate, group, followed by cyclocondensation with elimination of hydrogen chloride and formation of the corresponding 2-functionally substituted 4-tosyl-5-chloro-1,3-thiazoles. Further transformations of these compounds were studied, and a series of previously unknown types of 3-functionally substituted 1,3-thiazole derivatives were prepared.

  DOI：

  10.1023/a:1023337112138