2,6-dichloro-3-nitrobenzoic acid amide | 55775-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichloro-3-nitrobenzoic acid amide
• 英文别名: 2,6-Dichlor-3-nitro-benzamid；2,6-Dichloro-3-nitrobenzamide
• CAS: 55775-98-9
• 化学式: C₇H₄Cl₂N₂O₃
• 分子量: 235.026
• InChiKey: WZLQDHBDKJVBRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dichloro-3-nitrobenzoic acid amide 在 platinum on activated charcoal 水 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 3-Amino-6-chloro-2-hydroxy-benzamide
  参考文献：
  名称：

  Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor

  摘要：

  N,N'-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N'-diarylurea series. As was the case in the N,N'-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.067
• 作为产物：
  描述：

  2,6-二氯-3-硝基苯甲酸 在 氨 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2,6-dichloro-3-nitrobenzoic acid amide
  参考文献：
  名称：

  Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor

  摘要：

  N,N'-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N'-diarylurea series. As was the case in the N,N'-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.067

文献信息

• 3-aminobenzoylphenylureas useful for controlling parasites and insects
  申请人：Ciba-Geigy Corporation

  公开号：US04946854A1

  公开（公告）日：1990-08-07

  Novel compounds of formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8 and R.sup.9, independently of the others, is H or halogen, R.sup.4 is H, R.sup.10 CO-- or R.sup.11 NHCO-- wherein R.sup.10 is a C.sub.1 -C.sub.4 alkyl group which is unsubstituted or substituted by one to three identical or different substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 - acyloxy and --COOG, wherein G is H, an alkali metal cation or an alkaline earth metal cation, and R.sup.11 is an unsubstituted or halo-substituted C.sub.1 -C.sub.4 alkyl or phenyl group, each of R.sup.5 and R.sup.6, independently of the other, is H, halogen, alkyl or haloalkyl and X is O, S(O)n or NH wherein n is 0, 1 or 2, the preparation of the novel compounds and their use against parasites in and on productive livestock and against insect pests, and novel starting materials and their preparation.

  化合物I的新颖化合物##STR1##其中R.sup.1、R.sup.2、R.sup.3、R.sup.7、R.sup.8和R.sup.9中的每一个，独立于其他者，为H或卤素，R.sup.4为H，R.sup.10 CO--或R.sup.11 NHCO--其中R.sup.10是未取代或取代的C.sub.1 -C.sub.4烷基基团，取代基可为卤素、C.sub.1 -C.sub.4烷氧基、C.sub.1 -C.sub.4酰氧基和--COOG中选择的一个到三个相同或不同的取代基，其中G为H、碱金属阳离子或碱土金属阳离子，R.sup.11为未取代或卤素取代的C.sub.1 -C.sub.4烷基或苯基，R.sup.5和R.sup.6中的每一个，独立于其他者，为H、卤素、烷基或卤代烷基，X为O、S(O)n或NH，其中n为0、1或2，新化合物的制备及其在生产性家畜体内外寄生虫和昆虫害虫中的应用，以及新的起始材料及其制备。
• [EN] INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE L'INTÉGRINE ALPHA 2 BÊTA 1 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2021222789A1

  公开（公告）日：2021-11-04

  Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

  本公开的内容包括阿尔法2贝塔1整合素的抑制剂以及使用这些抑制剂的方法。
• Il-8 receptor antagonists
  申请人：——

  公开号：US20040132694A1

  公开（公告）日：2004-07-08

  This invention relates to the novel use of amide squaramides in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

  本发明涉及酰胺并四氢喹啉酰胺在治疗由趋化因子白细胞介素-8（IL-8）介导的疾病状态中的新用途。
• IL-8 receptor antagonists
  申请人：Palovich R. Michael

  公开号：US20060084661A1

  公开（公告）日：2006-04-20

  This invention relates to the novel use of amide squaramides in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

  本发明涉及酰胺方酰胺在治疗由趋化因子Interleukin-8（IL-8）介导的疾病状态中的新用途。
• Romanowski, Jacek; Eckstein, Zygmunt, Polish Journal of Chemistry, 1984, vol. 58, # 1-3, p. 263 - 268
  作者：Romanowski, Jacek、Eckstein, Zygmunt

  DOI：——

  日期：——