2-(benzyloxycarbonylamino)-2-methylpropane-1-sulfonamide | 667452-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzyloxycarbonylamino)-2-methylpropane-1-sulfonamide
• 英文别名: benzyl 2-methyl-1-sulfamoylpropan-2-ylcarbamate；benzyl N-(2-methyl-1-sulfamoylpropan-2-yl)carbamate
• CAS: 667452-42-8
• 化学式: C₁₂H₁₈N₂O₄S
• 分子量: 286.352
• InChiKey: MFEBNJQWIGCTNV-UHFFFAOYSA-N

物化性质

• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(benzyloxycarbonylamino)-2-methylpropane-1-sulfonamide 、 溶剂黄146 在 palladium 10% on activated carbon 氢气 作用下， 反应 10.0h， 生成 2-amino-2-methylpropane-1-sulfonamide acetate
  参考文献：
  名称：

  EP1544193

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(苄氧基羰基)氨基-2-甲基丙基硫代乙酸酯 在 盐酸 、 sodium hypochlorite 、 氨 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.25h， 生成 2-(benzyloxycarbonylamino)-2-methylpropane-1-sulfonamide
  参考文献：
  名称：

  WO2008/83347

  摘要：

  公开号：

文献信息

• Sulfonamide derivatives, insecticides for agricultural and horticultural use, and usage thereof
  申请人：Yamaguchi Minoru

  公开号：US20060167315A1

  公开（公告）日：2006-07-27

  Sulfonamide derivatives represented by general formula (I) or salts thereof; insecticides for agricultural and horticultural use containing the same as the active ingredient; and usage thereof: [wherein A is optionally substituted (C 1 -C 6 )alkylene, (C 3 -C 6 )alkenylene or the like; R 1 is H, optionally substituted (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl, (C 3 -C 6 )cycloalkyl or the like; R 2 , R 3 and R 4 are each H, (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl or the like, or R 2 and A or R 2 and R 1 may form a 3- to 8-membered ring which may be interrupted by one to three atoms selected from among Of S and N; Q is C or N; X and Y are each halogen, CN, NO 2 , (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl or the like; m is 0 to 2; n is 0 to 3; and two adjacent Xs or Ys on the aromatic ring may be united to form a fused ring]. The compounds exhibit excellent insecticidal activity against insect pests resistant to existing pesticides even when applied in dosages lower than those of similar pesticides.

  通式（I）或其盐所代表的磺胺衍生物；农业和园艺用杀虫剂，其包含作为活性成分的磺胺衍生物；以及其用途：[其中A是可选取代的（C1-C6）烷基，（C3-C6）烯基或类似物；R1为H，可选取代的（C1-C6）烷基，（C3-C6）烯基，（C3-C6）环烷基或类似物；R2，R3和R4分别为H，（C1-C6）烷基，（C3-C6）烯基或类似物，或R2和A或R2和R1可以形成一个3-到8-成员的环，该环可以被选自O、S和N的1-3个原子所中断；Q为C或N；X和Y分别为卤素，CN，NO2，（C1-C6）烷基，（C2-C6）烯基或类似物；m为0到2；n为0到3；芳香环上的两个相邻的X或Y可以合并形成一个融合环]。这些化合物表现出优异的杀虫活性，对于已经对现有杀虫剂产生抗性的害虫来说，即使在比类似杀虫剂更低的剂量下应用，也能够有效地控制。
• SULFONAMIDE DERIVATIVES, INSECTICIDES FOR AGRICULTURAL AND HORTICULTURAL USE, AND USAGE THEREOF
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP1544193A1

  公开（公告）日：2005-06-22

  Sulfonamide derivatives represented by general formula (I) or salts thereof; insecticides for agricultural and horticultural use containing the same as the active ingredient; and usage thereof:    [wherein A is optionally substituted (C1-C6)alkylene, (C3-C6)alkenylene or the like; R1 is H, optionally substituted (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)cycloalkyl or the like; R2, R3 and R4 are each H, (C1-C6)alkyl, (C3-C6)alkenyl or the like, or R2 and A or R2 and R1 may form a 3- to 8-membered ring which may be interrupted by one to three atoms selected from among O, S and N; Q is C or N; X and Y are each halogen, CN, NO2, (C1-C6)alkyl, (C2-C6)alkenyl or the like; m is 0 to 2; n is 0 to 3; and two adjacent Xs or Ys on the aromatic ring may be united to form a fused ring]. The compounds exhibit excellent insecticidal activity against insect pests resistant to existing pesticides even when applied in dosages lower than those of similar pesticides.

  由通式(I)代表的磺酰胺衍生物或其盐类；含有相同活性成分的农业和园艺用杀虫剂；及其用途： [其中 A 是任选取代的(C1-C6)亚烷基、(C3-C6)烯基或类似物；R1 是 H、任选取代的(C1-C6)烷基、(C3-C6)烯基、(C3-C6)环烷基或类似物；R2、R3 和 R4 各自是 H、(C1-C6)烷基、(C3-C6)烯基或类似物，或 R2 和 A 或 R2 和 R1 可形成 3 至 8 元环，该环可被 1 至 3 个选自 O、S 和 N 的原子打断；Q是C或N；X和Y各自是卤素、CN、NO2、(C1-C6)烷基、(C2-C6)烯基或类似物；m是0至2；n是0至3；芳香环上相邻的两个X或Y可以结合形成一个融合环]。这些化合物对对现有杀虫剂有抗药性的害虫具有极佳的杀虫活性，即使施用剂量低于同类杀虫剂。
• N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents
  作者：Eddy Low、Satheesh Nair、Timothy Shiau、Barbara Belisle、Dmitri Debabov、Chris Celeri、Meghan Zuck、Ron Najafi、Nafsika Georgopapadakou、Rakesh Jain

  DOI：10.1016/j.bmcl.2008.10.114

  日期：2009.1

  2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt (2a), a stable derivative of endogenous N,N-dichlorotaurine (1), has been identified and is under development as a topical antimicrobial agent. Structure-activity relationships of analogs were explored to achieve optimal antimicrobial activity with minimal mammalian toxicity while maintaining the desired stability. All the analogs synthesized showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans in the range of 1-128 mu g/mL and cytotoxicity against mammalian L929 cells in the range 80-1900 mu g/mL. (C) 2008 Elsevier Ltd. All rights reserved.
• N-HALOGENATED AMINO COMPOUNDS AND DERIVATIVES
  申请人：NovaBay Pharmaceuticals, Inc.

  公开号：EP2120965B1

  公开（公告）日：2014-11-05
• US7161032B2
  申请人：——

  公开号：US7161032B2

  公开（公告）日：2007-01-09