N-(2-hydroxyphenyl)malonamic acid | 211111-51-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxyphenyl)malonamic acid
• 英文别名: 3-(2-Hydroxyanilino)-3-oxopropanoic acid
• CAS: 211111-51-2
• 化学式: C₉H₉NO₄
• mdl: MFCD20638773
• 分子量: 195.175
• InChiKey: TXXGQRAXXNILFB-UHFFFAOYSA-N

物化性质

• 沸点：
  493.4±30.0 °C(Predicted)
• 密度：
  1.477±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丁香醛 、 N-(2-hydroxyphenyl)malonamic acid 在 盐酸胍 、 溶剂黄146 、 potassium hydroxide 作用下， 反应 14.0h， 以72%的产率得到3-(3,5-dimethoxy-4-hydroxyphenyl)-2-[[(2-hydroxyphenyl)amino]carbonyl]prop-(2E)-enoic acid
  参考文献：
  名称：

  avenanthramides类似物的替代方法及其抗自由基活性

  摘要：

  摘要本文致力于通过丙二酸单苯胺与芳香醛的缩合合成芳基丙二酸单苯胺和肉桂酰基苯胺。提出的合成路线应用简单，便宜且可商购的芳族醛和胺，因此克服了涉及羟基肉桂酸衍生物的传统方案。此外，提出了一种温和有效的吡啶介导的芳基丙二酸丙二酸单苯胺中C sp 2处羧基的羧基脱羧，从而导致肉桂酰基苯胺。通过X射线分析另外批准了所获得的选定的亚芳基衍生物的结构。研究了合成化合物的抗自由基性能（2,2-二苯基-1-吡咯肼基和丙氧基测试）和结构-活性关系。 图形概要

  DOI：

  10.1007/s00706-018-2288-6
• 作为产物：
  描述：

  2-((tert-butyldimethylsilyl)oxy)aniline 在 氢氧化钾 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 N-(2-hydroxyphenyl)malonamic acid
  参考文献：
  名称：

  苯并恶嗪酮、其降解产物和类似物的构效关系 (SAR) 研究。对标准目标物种（STS）的植物毒性。

  摘要：

  苯并恶嗪酮 2,4-二羟基-7-甲氧基-(2H)-1,4-苯并恶嗪-3(4H)-酮 (DIMBOA) 和 2,4-二羟基-(2H)-1,4-苯并恶嗪-3(4H) )-one (DIBOA) 被认为是了解禾本科作物（例如玉米 (Zea mays L.)、小麦 (Triticum aestivum L.) 和黑麦 (Secale Cereale L.)）化感作用现象的关键化合物。在环境中观察到的这些化合物的降解过程（其中土壤微生物直接参与）可能会影响这些植物的潜在化感活性。我们在这项工作中提出了一项完整的结构-活性关系研究，该研究基于观察到的 DIMBOA、DIBOA 及其主要降解产物以及它们的几种合成类似物的植物毒性作用。它们对标准目标物种 (STS) 的影响进行了评估，其中包括作为单子叶植物的 Triticum aestivum L.（小麦）和 Allium cepa L.（洋葱）以及 Lepidium

  DOI：

  10.1021/jf0484071

文献信息

• Structure−Activity Relationships (SAR) Studies of Benzoxazinones, Their Degradation Products and Analogues. Phytotoxicity on Standard Target Species (STS)
  作者：Francisco A. Macías、David Marín、Alberto Oliveros-Bastidas、Diego Castellano、Ana M. Simonet、José M. G. Molinillo

  DOI：10.1021/jf0484071

  日期：2005.2.1

  Benzoxazinones 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one (DIMBOA) and 2,4-dihydroxy-(2H)-1,4-benzoxazin-3(4H)-one (DIBOA) have been considered key compounds for understanding allelopathic phenomena in Gramineae crop plants such as corn (Zea mays L.), wheat (Triticum aestivum L.), and rye (Secale cereale L.). The degradation processes in the environment observed for these compounds, in which

  苯并恶嗪酮 2,4-二羟基-7-甲氧基-(2H)-1,4-苯并恶嗪-3(4H)-酮 (DIMBOA) 和 2,4-二羟基-(2H)-1,4-苯并恶嗪-3(4H) )-one (DIBOA) 被认为是了解禾本科作物（例如玉米 (Zea mays L.)、小麦 (Triticum aestivum L.) 和黑麦 (Secale Cereale L.)）化感作用现象的关键化合物。在环境中观察到的这些化合物的降解过程（其中土壤微生物直接参与）可能会影响这些植物的潜在化感活性。我们在这项工作中提出了一项完整的结构-活性关系研究，该研究基于观察到的 DIMBOA、DIBOA 及其主要降解产物以及它们的几种合成类似物的植物毒性作用。它们对标准目标物种 (STS) 的影响进行了评估，其中包括作为单子叶植物的 Triticum aestivum L.（小麦）和 Allium cepa L.（洋葱）以及 Lepidium
• Method of using an electrochemical test sensor
  申请人：Ascensia Diabetes Care Holdings AG

  公开号：US10690614B2

  公开（公告）日：2020-06-23

  A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.

  在电化学测试传感器中执行一种区分对照溶液和样品的方法。该方法包括在控制溶液中加入控制标记。控制溶液包括控制标记和分析物。测试传感器包括工作电极、对电极和试剂。向测试传感器施加电势，使对照标记和分析物氧化。测量由此产生的电流。向测试传感器施加的电位低于另一电位，该电位足以氧化被分析物而不氧化对照标记。测量由此产生的电流。根据测量到的电流确定是否存在对照溶液或样品。为增加测得的电流，可向对照溶液中添加盐，其添加量足以使电流比不添加盐的对照溶液增加至少 5%。
• N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases
  作者：Oscar Saavedra、Stephen Claridge、Lijie Zhan、Franck Raeppel、Marie-Claude Granger、Stéphane Raeppel、Michael Mannion、Frédéric Gaudette、Nancy Zhou、Ljubomir Isakovic、Naomy Bernstein、Robert Déziel、Hannah Nguyen、Normand Beaulieu、Carole Beaulieu、Isabelle Dupont、James Wang、A. Robert Macleod、Jeffrey M. Besterman、Arkadii Vaisburg

  DOI：10.1016/j.bmcl.2009.10.095

  日期：2009.12

  A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC50 values in the low nanomolar range in vitro and were efficacious in human tumor xenograft models in mice in vivo. (C) 2009 Elsevier Ltd. All rights reserved.
• Control markers for auto-detection of control solution and method of use
  申请人：Lin Jing

  公开号：US20090148875A1

  公开（公告）日：2009-06-11

  A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
• Control Solution For Use In An Electrochemical System
  申请人：Bayer HealthCare LLC

  公开号：US20130078724A1

  公开（公告）日：2013-03-28

  A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.