erythro-5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>-1-octyl tosylate | 120578-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: erythro-5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>-1-octyl tosylate
• CAS: 120578-89-4
• 化学式: C₃₉H₆₀O₅SSi₂
• 分子量: 697.139
• InChiKey: LUMAIQXCABOXIS-AARKOHAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.62
• 重原子数：
  47.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  erythro-5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>-1-octyl tosylate 在 potassium fluoride 、 18-冠醚-6 作用下， 以 四氢呋喃 为溶剂， 以89%的产率得到erythro-5,6-bis(4-hydroxyphenyl)-1-octyl tosylate
  参考文献：
  名称：

  Hexestrol-linked cytotoxic agents: synthesis and binding affinity for estrogen receptors

  摘要：

  With the erythro-hexestrol derivative 2 as the starting material, a variety of cytotoxic linked hexestrol (HEX) compounds were prepared including the HEX-N-lost derivative 36, the HEX-(chloroethyl)nitrosourea 38, the HEX-cyclophosphamide 44, and the HEX-epoxide 68. Relative binding affinity to estradiol receptors were in the magnitude of 1%, similar to that of comparable diethylstilbestrol compounds. HEX derivatives with long polyether spacers (64, 65, 70, 71) showed no significant decrease in binding affinity in contrast to derivatives with other bulky side chains.

  DOI：

  10.1021/jm00127a023
• 作为产物：
  描述：

  tert-butyldimethylsilyl (5R*,6S*)-5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>octanoate 在 吡啶 、 甲醇 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 erythro-5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>-1-octyl tosylate
  参考文献：
  名称：

  Hexestrol-linked cytotoxic agents: synthesis and binding affinity for estrogen receptors

  摘要：

  With the erythro-hexestrol derivative 2 as the starting material, a variety of cytotoxic linked hexestrol (HEX) compounds were prepared including the HEX-N-lost derivative 36, the HEX-(chloroethyl)nitrosourea 38, the HEX-cyclophosphamide 44, and the HEX-epoxide 68. Relative binding affinity to estradiol receptors were in the magnitude of 1%, similar to that of comparable diethylstilbestrol compounds. HEX derivatives with long polyether spacers (64, 65, 70, 71) showed no significant decrease in binding affinity in contrast to derivatives with other bulky side chains.

  DOI：

  10.1021/jm00127a023