2-N-methyl-4-(morpholin-4-ylmethyl)benzene-1,2-diamine | 1224582-31-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-N-methyl-4-(morpholin-4-ylmethyl)benzene-1,2-diamine
• CAS: 1224582-31-3
• 化学式: C₁₂H₁₉N₃O
• 分子量: 221.302
• InChiKey: KHFQBBVHGVPWSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-N-methyl-4-(morpholin-4-ylmethyl)benzene-1,2-diamine 、 氯乙酸酐 以 四氢呋喃 为溶剂， 生成 2-chloro-N-[2-[(chloroacetyl)amino]-5-(morpholin-4-ylmethyl)phenyl]-N-methylacetamide chloroacetic acid salt
  参考文献：
  名称：

  The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

  摘要：

  Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.094
• 作为产物：
  描述：

  N-methyl-5-(morpholin-4-ylmethyl)-2-nitroaniline 在 5% Pd(II)/C(eggshell) 、 氢气 作用下， 以 四氢呋喃 为溶剂， 生成 2-N-methyl-4-(morpholin-4-ylmethyl)benzene-1,2-diamine
  参考文献：
  名称：

  The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

  摘要：

  Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.094

文献信息

• [EN] PHARMACEUTICAL COMBINATIONS<br/>[FR] COMBINAISONS PHARMACEUTIQUES
  申请人：ASTEX THERAPEUTICS LTD

  公开号：WO2008001101A2

  公开（公告）日：2008-01-03

  [EN] The invention provides combinations of an ancillary compound of the formula (0): and a compound of the formula (I'): Also provided are crystalline forms of the constituent compounds, methods for making them and their uses in treating cancers.
  [FR] La présente invention concerne des combinaisons d'un composé ancillaire de formule (0) : et d'un composé de formule (I') : La présente invention concerne également les formes cristallines des composés constitutifs, leurs méthodes de fabrication et leurs applications au traitement des cancers.