2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one | 926013-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one
• 英文别名: 3a-(3,4-dimethoxyphenyl)-3-methylsulfanyl-1-[(1R)-1-naphthalen-1-ylethyl]-3,4,5,6-tetrahydroindol-2-one
• CAS: 926013-38-9
• 化学式: C₂₉H₃₁NO₃S
• 分子量: 473.636
• InChiKey: UKVHFYQURXTMHQ-JITVNWOXSA-N

物化性质

• 沸点：
  673.2±55.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  64.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one 在 镍 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以94%的产率得到2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one
  参考文献：
  名称：

  Stereoselective synthesis of cis and trans-fused 3a-aryloctahydroindoles using cyclization of N-vinylic α-(methylthio)acetamides: synthesis of (−)-mesembrane

  摘要：

  Treatment of N-(2-arylcyclohex-1-en-1-yl)-alpha-(methylthio)acetamides with N-chlorosuccinimide (NCS) gave 3a-aryl-2,3,3a,4, 5,6-hexahydro-3-(methylthio)indol-2-ones. Desulfurization of the cyclization products followed by a catalytic hydrogenation of the resulting hexahydroindol-2-ones gave predominantly or exclusively trans-fused octahydroindol-2-ones. On the other hand, reduction of the desulfurization products with Et3SiH in CF3CO2H exclusively provided cis-fused octahydroindol-2-ones. A chiral induction of N-[2-(3,4-dimethoxy)phenylcyclohex-1-en-1-yl]-alpha-(methylthio)acetamide having an (R)-1-(l-naphthyl)ethyl group on the nitrogen atom led to the synthesis of (-)-mesembrane and (-)-trans-mesembrane. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.153
• 作为产物：
  描述：

  2-(3,4-dimethoxyphenyl)cyclohexanone 在 4-二甲氨基吡啶 、 N-氯代丁二酰亚胺 、 N,N-二甲基苯胺 作用下， 以 四氯化碳 为溶剂， 反应 0.5h， 生成 2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one
  参考文献：
  名称：

  Saito, Miho; Matsuo, Jun-ichi; Uchiyama, Masahiko, Heterocycles, 2006, vol. 69, # 1, p. 69 - 72

  摘要：

  DOI：

文献信息

• Saito, Miho; Matsuo, Jun-ichi; Uchiyama, Masahiko, Heterocycles, 2006, vol. 69, # 1, p. 69 - 72
  作者：Saito, Miho、Matsuo, Jun-ichi、Uchiyama, Masahiko、Ishibashi, Hiroyuki

  DOI：——

  日期：——
• Stereoselective synthesis of cis and trans-fused 3a-aryloctahydroindoles using cyclization of N-vinylic α-(methylthio)acetamides: synthesis of (−)-mesembrane
  作者：Miho Saito、Jun-ichi Matsuo、Hiroyuki Ishibashi

  DOI：10.1016/j.tet.2007.03.153

  日期：2007.6

  Treatment of N-(2-arylcyclohex-1-en-1-yl)-alpha-(methylthio)acetamides with N-chlorosuccinimide (NCS) gave 3a-aryl-2,3,3a,4, 5,6-hexahydro-3-(methylthio)indol-2-ones. Desulfurization of the cyclization products followed by a catalytic hydrogenation of the resulting hexahydroindol-2-ones gave predominantly or exclusively trans-fused octahydroindol-2-ones. On the other hand, reduction of the desulfurization products with Et3SiH in CF3CO2H exclusively provided cis-fused octahydroindol-2-ones. A chiral induction of N-[2-(3,4-dimethoxy)phenylcyclohex-1-en-1-yl]-alpha-(methylthio)acetamide having an (R)-1-(l-naphthyl)ethyl group on the nitrogen atom led to the synthesis of (-)-mesembrane and (-)-trans-mesembrane. (c) 2007 Elsevier Ltd. All rights reserved.