4,4'-hexanediyldioxy-bis-benzamidine; dihydrochloride | 50357-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,4'-hexanediyldioxy-bis-benzamidine; dihydrochloride
• 英文别名: 4,4'-Hexandiyldioxy-bis-benzamidin; Dihydrochlorid；4-[6-(4-Carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;hydrochloride
• CAS: 50357-46-5
• 化学式: C₂₀H₂₆N₄O₂*2ClH
• 分子量: 427.374
• InChiKey: SPNFMOVANUEVRR-UHFFFAOYSA-N

物化性质

• 熔点：
  250-254°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  4

安全信息

• 海关编码：
  2925290090

反应信息

• 作为产物：
  描述：

  sodium 4-cyanophenolate 在 盐酸 、 乙醇 作用下， 生成 4,4'-hexanediyldioxy-bis-benzamidine; dihydrochloride
  参考文献：
  名称：

  Ashley et al., Journal of the Chemical Society, 1942, p. 103,107

  摘要：

  DOI：

文献信息

• Preparation and characterisation of hexamidine salts
  作者：Nicola Parisi、Paul J. Matts、Rebecca Lever、Jonathan Hadgraft、Majella E. Lane

  DOI：10.1016/j.ijpharm.2015.07.071

  日期：2015.9

  range of solvents. NMR analysis confirmed the preparation of HEX H from HEX D. Thermal analysis indicated the melting points of HEX D and HEX H were 225°C and 266°C respectively. HPLC analysis confirmed the purity of both salts. LogD values at pH 7.4 were -0.74 for HEX D and -0.70 for HEX H respectively. The physicochemical properties of two HEX salts have been established using a range of analytical

  自1950年代以来，己am二羟乙基磺酸盐（HEX D）已在个人护理行业和许多非处方（OTC）药品中用作抗菌剂。最近，还研究了该化合物对皮肤健康的有益作用。令人惊讶地，在文献中仅有很少的信息描述了该化合物的物理化学性质。因此，这项工作的目的是对HEX D及其二盐酸盐（HEX H）进行全面的表征。通过简单的酸加成反应由HEX D制备HEXH。两种盐都使用核磁共振（NMR），差示扫描量热法（DSC）和热重分析（TGA）进行了表征。开发了一种新的高效液相色谱方法，并针对这两种化合物进行了验证。还测定了水溶液中的pH值以及辛醇和pH 7.4缓冲液之间的各自分配系数。最后，在一系列溶剂中进行了溶解度和短期稳定性研究。NMR分析证实由HEX D制备HEXH。热分析表明HEX D和HEX H的熔点分别为225℃和266℃。HPLC分析证实了两种盐的纯度。pH 7.4的LogD值对于HEX D为-0.74，对于HEX
• Hemorrhoid treatment pad
  申请人：The Procter and Gamble Company

  公开号：EP2085099A1

  公开（公告）日：2009-08-05

  A hemorrhoid treatment pad, the hemorrhoid treatment pad having a substance on a body facing surface thereof, the substance comprising a skin care composition. The skin care composition can have from about 0.001% to about 0.1% by weight of hexamidine; from about 0.001% to about 10% by weight of zinc oxide; from about 0.01% to about 10% by weight of niacinamide; and a carrier.

  一种痔疮治疗垫，该痔疮治疗垫在其面向身体的表面上有一种物质，该物质包括一种护肤组合物。护肤组合物可以有约 0.001%至约 0.1%（按重量计）的己脒；约 0.001%至约 10%（按重量计）的氧化锌；约 0.01%至约 10%（按重量计）的烟酰胺；以及载体。
• Sanitary napkins with hydrophobic lotions
  申请人：The Procter and Gamble Company

  公开号：EP2103315A2

  公开（公告）日：2009-09-23

  A catamenial device, said device comprising: a topsheet having a body facing surface, wherein said topsheet has a level of hydrophobicity, a lotion composition applied to at least a portion of at least to the body facing surface of said topsheet, said lotion having a level of hydrophobicity equal or greater than that of said topsheet, said lotion composition comprising from about 60% to about 99.9% by weight of the carrier wherein the carrier is selected from the group consisting of petroleum-based hydrocarbons having from about 4 to about 32 carbon atoms, fatty alcohols having from about 12 to about 24 carbon atoms, lower alcohols having from about 1 to about 6 carbon atoms, low molecular weight glycols and polyols, lanolin, and mixtures thereof; a backsheet joined to said topsheet; and an absorbent core disposed between said topsheet and said backsheet.

  一种导尿装置，所述装置包括：具有面向身体表面的表皮，其中所述表皮具有一定的疏水性；涂抹在所述表皮面向身体表面的至少一部分上的乳液组合物，所述乳液的疏水性等于或大于所述表皮的疏水性，所述乳液组合物包括约 60% 至约 99.9%（重量）的载体，其中所述载体选自由以下组成的组：具有约4至约32个碳原子的石油基碳氢化合物、具有约12至约24个碳原子的脂肪醇、具有约1至约6个碳原子的低级醇、低分子量乙二醇和多元醇、羊毛脂，以及它们的混合物；与所述表皮连接的背板；以及设置在所述表皮和所述背板之间的吸收芯。
• Absorbent articles comprising glyceride copolymers
  申请人：The Procter & Gamble Company

  公开号：US10265434B2

  公开（公告）日：2019-04-23

  The present invention relates to absorbent articles comprising species of glyceride copolymers that provide unexpectedly improved softening performance and formulability.

  本发明涉及由各种甘油酯共聚物组成的吸水性物品，其软化性能和可配制性出乎意料地得到改善。
• Sanitary napkins capable of taking complex three-dimensional shape in use
  申请人：The Procter & Gamble Company

  公开号：US10568781B2

  公开（公告）日：2020-02-25

  A catamenial device is disclosed. The device having a topsheet, a backsheet joined to said topsheet, and an absorbent core disposed between the topsheet and the backsheet. The absorbent core has a perimeter, a longitudinal centerline, and a transverse centerline. The catamenial device further having a visible pattern having at least one circle and at least two or more slots that are visible when viewing the topsheet.

  公开了一种导尿装置。该装置具有顶板、与所述顶板连接的背板以及位于顶板和背板之间的吸收芯。吸收芯具有周边、纵向中心线和横向中心线。该导尿装置还具有一个可见图案，该图案具有至少一个圆圈和至少两个或更多槽，在查看表层时可见。