2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | 933985-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide
• 英文别名: 4-chloro-N-[3-[[2-[(2-chloroacetyl)amino]-1,3-thiazol-4-yl]methyl]-5-(2-hydrazinyl-2-oxoethyl)sulfanyl-1,2,4-triazol-4-yl]benzamide
• CAS: 933985-29-6
• 化学式: C₁₇H₁₆Cl₂N₈O₃S₂
• 分子量: 515.404
• InChiKey: KEUUTBKQXWXFLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  211
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide 、 氯乙酰氯 在 aluminum oxide 作用下， 生成 4-chloro-N-[3-[[2-[(2-chloroacetyl)amino]thiazol-4-yl]methyl]-5-[2-[2-(2-chloroacetyl)hydrazino]-2-oxo-ethyl]sulfanyl-1,2,4-triazol-4-yl]benzamide
  参考文献：
  名称：

  Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease

  摘要：

  A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.01.043
• 作为产物：
  描述：

  Methyl 2-[[5-[[2-[(2-chloroacetyl)amino]thiazol-4-yl]methyl]-4-[(4-chlorobenzoyl)amino]-1,2,4-triazol-3-yl]sulfanyl]acetate 在 aluminum oxide 、 一水合肼 作用下， 以83%的产率得到2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide
  参考文献：
  名称：

  Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease

  摘要：

  A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.01.043

文献信息

• Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease
  作者：Mahendra Ramesh Shiradkar、Kalyan Chakravarthy Akula、Varaprasad Dasari、Vijayakumar Baru、Bhoomeshwar Chiningiri、Santosh Gandhi、Ranjit Kaur

  DOI：10.1016/j.bmc.2007.01.043

  日期：2007.4

  A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.