Directed metalation of tertiary benzamides. Silicon protection of ortho sites and ortho methyl groups
作者:R. J. Mills、V. Snieckus
DOI:10.1021/jo00157a047
日期:1983.5
Directed ortho metalation of N,N-diethylbenzamides. Silicon protection of ortho sites and the o-methyl group
作者:Robert J. Mills、Nicholas J. Taylor、Victor Snieckus
DOI:10.1021/jo00279a028
日期:1989.9
MILLS, ROBERT J.;TAYLOR, NICHOLAS J.;SNIECKUS, VICTOR, J. ORG. CHEM., 54,(1989) N8, C. 4372-4385
作者:MILLS, ROBERT J.、TAYLOR, NICHOLAS J.、SNIECKUS, VICTOR
DOI:——
日期:——
MILLS, R. I.;SNIECKUS, V., J. ORG. CHEM., 1983, 48, N 9, 1565-1568
作者:MILLS, R. I.、SNIECKUS, V.
DOI:——
日期:——
Rational design of inhibitors of VirA–VirG two-component signal transduction
作者:Justin Maresh、Jin Zhang、Yih-Ling Tzeng、Nora A. Goodman、David G. Lynn
DOI:10.1016/j.bmcl.2007.04.018
日期:2007.6
VirA-VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4,6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found to have the highest activity, making it the most potent developed inhibitor of virulence gene expression in Agrobacterium. (c) 2007 Elsevier Ltd. All rights reserved.