benzyl (3-(3-methoxylphenyl)-2-propynyl)oxycarbamate | 1287768-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (3-(3-methoxylphenyl)-2-propynyl)oxycarbamate
• 英文别名: benzyl N-[3-(3-methoxyphenyl)prop-2-ynoxy]carbamate
• CAS: 1287768-70-0
• 化学式: C₁₈H₁₇NO₄
• 分子量: 311.337
• InChiKey: SUXXVQBGQJLGIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl (3-(3-methoxylphenyl)-2-propynyl)oxycarbamate 在 bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以98%的产率得到benzyl 2,5-dihydro-4-iodo-3-(3-methoxylphenyl)-2H-isoxazole-2-carboxylate
  参考文献：
  名称：

  Iodocyclization of Hydroxylamine Derivatives Based on the Control of Oxidative Aromatization Leading to 2,5-Dihydroisoxazoles and Isoxazoles

  摘要：

  An efficient method for the synthesis of 2,5-dihydroisoxazoles and isoxazoles using iodocyclization of N-alkoxycarbonyl O-propargylic hydroxylamines has been developed. 2,5-Dihydro-4-iodoisoxazole underwent the cross-coupling reactions without aromatization to afford polyfunctionalized 2,5-dihydroisoxazoles. This process was applied to the preparation of valdecoxib and its 2,5-dihydro-derivative.

  DOI：

  10.1021/jo200407b
• 作为产物：
  描述：

  3-(3-甲氧基苯基)-2-丙炔-1-醇 在 溴 、 碳酸氢钠 、 一水合肼 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三苯基膦 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 benzyl (3-(3-methoxylphenyl)-2-propynyl)oxycarbamate
  参考文献：
  名称：

  Iodocyclization of Hydroxylamine Derivatives Based on the Control of Oxidative Aromatization Leading to 2,5-Dihydroisoxazoles and Isoxazoles

  摘要：

  An efficient method for the synthesis of 2,5-dihydroisoxazoles and isoxazoles using iodocyclization of N-alkoxycarbonyl O-propargylic hydroxylamines has been developed. 2,5-Dihydro-4-iodoisoxazole underwent the cross-coupling reactions without aromatization to afford polyfunctionalized 2,5-dihydroisoxazoles. This process was applied to the preparation of valdecoxib and its 2,5-dihydro-derivative.

  DOI：

  10.1021/jo200407b

文献信息

• Iodocyclization of Hydroxylamine Derivatives Based on the Control of Oxidative Aromatization Leading to 2,5-Dihydroisoxazoles and Isoxazoles
  作者：Takashi Okitsu、Kana Sato、Taterao M. Potewar、Akimori Wada

  DOI：10.1021/jo200407b

  日期：2011.5.6

  An efficient method for the synthesis of 2,5-dihydroisoxazoles and isoxazoles using iodocyclization of N-alkoxycarbonyl O-propargylic hydroxylamines has been developed. 2,5-Dihydro-4-iodoisoxazole underwent the cross-coupling reactions without aromatization to afford polyfunctionalized 2,5-dihydroisoxazoles. This process was applied to the preparation of valdecoxib and its 2,5-dihydro-derivative.