2-[4-(3-Cyclohexyl-4-hydroxyphenoxy)-3,5-dimethylanilino]-2-oxoacetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(3-Cyclohexyl-4-hydroxyphenoxy)-3,5-dimethylanilino]-2-oxoacetic acid
• 化学式: C₂₂H₂₅NO₅
• 分子量: 383.444
• InChiKey: HDCOTUFXVBSNHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-1,3-二甲基-5-硝基苯 在 palladium on activated charcoal sodium hydroxide 、 氢气 、 三溴化硼 、 sodium hydride 作用下， 以 乙醇 为溶剂， 生成 2-[4-(3-Cyclohexyl-4-hydroxyphenoxy)-3,5-dimethylanilino]-2-oxoacetic acid
  参考文献：
  名称：

  Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to l-thyronine

  摘要：

  The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T-3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00309-7

文献信息

• Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to l-thyronine
  作者：James L Stanton、Edna Cahill、Ronald Dotson、Jenny Tan、Hollis C Tomaselli、Jong M Wasvary、Zouhair F Stephan、Ronald E Steele

  DOI：10.1016/s0960-894x(00)00309-7

  日期：2000.8

  The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T-3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.