2,6-difluoro-N-[[4-[5-(4-fluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]phenyl]carbamoyl]benzamide | 1287686-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluoro-N-[[4-[5-(4-fluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]phenyl]carbamoyl]benzamide
• CAS: 1287686-53-6
• 化学式: C₂₃H₁₆F₃N₃O₃
• 分子量: 439.394
• InChiKey: MTYPXNULIDDLQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  79.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-nitrobenzohydroximoyl chloride 在 铁粉 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 2,6-difluoro-N-[[4-[5-(4-fluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]phenyl]carbamoyl]benzamide
  参考文献：
  名称：

  Design, Synthesis, and Insecticidal Evaluation of New Benzoylureas Containing Isoxazoline and Isoxazole Group

  摘要：

  Twenty-two new benzoylphenylureas containing isoxazoline and the isoxazole group were designed and synthesized, and their structures were characterized by (1)H NMR and elemental analysis (or FIRMS). The larvicidal activities against Oriental armyworm, mosquito, and diamondback moth of the new compounds were evaluated. Compounds I-1 and III-1 showed nearly the same level of insecticidal activity against Oriental armyworm as commercial insecticide Flucycloxuron and surprisingly exhibited much higher larvicidal activities against diamondback moth than Flucycloxuron.

  DOI：

  10.1021/jf200395g

文献信息

• Design, Synthesis, and Insecticidal Evaluation of New Benzoylureas Containing Isoxazoline and Isoxazole Group
  作者：Ranfeng Sun、Yongqiang Li、Lixia Xiong、Yuxiu Liu、Qingmin Wang

  DOI：10.1021/jf200395g

  日期：2011.5.11

  Twenty-two new benzoylphenylureas containing isoxazoline and the isoxazole group were designed and synthesized, and their structures were characterized by (1)H NMR and elemental analysis (or FIRMS). The larvicidal activities against Oriental armyworm, mosquito, and diamondback moth of the new compounds were evaluated. Compounds I-1 and III-1 showed nearly the same level of insecticidal activity against Oriental armyworm as commercial insecticide Flucycloxuron and surprisingly exhibited much higher larvicidal activities against diamondback moth than Flucycloxuron.