2-苯氧基乙烷-1-磺酰胺 | 100383-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-苯氧基乙烷-1-磺酰胺
• 英文名称: 2-phenoxyethane-1-sulfonamide
• 英文别名: 2-phenoxy-ethanesulfonic acid amide；2-Phenoxy-aethansulfonsaeure-amid；2-phenoxyethanesulfonamide
• CAS: 100383-38-8
• 化学式: C₈H₁₁NO₃S
• mdl: MFCD00754393
• 分子量: 201.246
• InChiKey: VJYBGWMDZPWAHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1H-indole-2-carboxylic acid 、 2-苯氧基乙烷-1-磺酰胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以27 mg的产率得到3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-((2-phenoxyethyl)sulfonyl)-1H-indole-2-carboxamide
  参考文献：
  名称：

  使用基于片段的方法发现 2-吲哚酰基磺酰胺骨髓细胞白血病 1 (Mcl-1) 抑制剂

  摘要：

  髓样细胞白血病-1 (Mcl-1) 是 Bcl-2 蛋白家族的成员，负责调节程序性细胞死亡。 Mcl-1 扩增是人类癌症中常见的遗传畸变，其过度表达有助于逃避细胞凋亡，并且是许多化疗的主要耐药机制之一。 Mcl-1 主要通过与含有促凋亡 BH3 的蛋白质相互作用来介导其作用，这些蛋白质通过利用其结合槽中的四个疏水性口袋实现对靶标的高亲和力。在这里，我们描述了使用基于片段的方法和基于结构的设计发现 Mcl-1 抑制剂。这些新型抑制剂对 Mcl-1 表现出低纳摩尔级的结合亲和力，选择性比 Bcl-xL 高 >500 倍。先导 Mcl-1 抑制剂与 Mcl-1 复合时的 X 射线结构提供了有关这些小分子如何与靶标结合的详细信息，并被广泛用于指导化合物优化。

  DOI：

  10.1021/acs.jmedchem.5b01660
• 作为产物：
  描述：

  2-苯氧基乙烷磺酰氯 在 乙醚 、 氨 作用下， 生成 2-苯氧基乙烷-1-磺酰胺
  参考文献：
  名称：

  Diaryliodonium Salts. XI. Salts Derived from Phenoxyacetic and β-Phenoxyethanesulfonic Acids^1,2

  摘要：

  DOI：

  10.1021/ja01521a020

文献信息

• Azo compound, tautomer thereof, and azo dye
  申请人：Fujita Akinori

  公开号：US20060009627A1

  公开（公告）日：2006-01-12

  An azo compound or a tautomer thereof, wherein the azo compound is represented by the following Formula (1). In Formula (1), R 1 represents a hydrogen atom, alkyl group, aryl group, acyl group, carbamoyl group, alkylsulfonyl group, arylsulfonyl group, or heterocyclic group; R 2 represents —NR 5 R 6 or —OR 7 ; R 5 and R 6 each independently represent a hydrogen atom, alkyl group, aryl group, acyl group, carbamoyl group, alkylsulfonyl group, or arylsulfonyl group; R 7 represents an alkyl group or aryl group; R 3 represents a hydrogen atom, alkyl group, aryl group, alkoxy group, aryloxy group, acylamino group, carbamoylamino group, alkylsulfonylamino group, or arylsulfonylamino group; n is an integer of 3 to 5; and each R 4 , of which there are n in number, independently represents an alkyl group, aryl group, alkoxy group, aryloxy group, amino group, alkylthio group, arylthio group, acylamino group, alkylsulfonylamino group, or arylsulfonylamino group, and one R 4 may bind to another R 4 forming a ring.
• COLORING COMPOSITION, CURED FILM, COLOR FILTER, METHOD FOR MANUFACTURING COLOR FILTER, SOLID-STATE IMAGING DEVICE, AND IMAGE DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20160327858A1

  公开（公告）日：2016-11-10

  Provided are a coloring composition which makes it possible to providing a color filter having surface unevenness relieved; and a cured film, a color filter, a method for manufacturing the color filter, a solid-state imaging device, and an image display device, each of which uses the coloring composition. The coloring composition includes a colorant compound represented by General Formula (1), a curable compound, and a solvent, in which one of Ar 1 and Ar 2 is a group represented by General Formula (2), and the other of Ar 1 and Ar 2 is a hydrogen atom, a group represented by the following General Formula (2), or the like, R 5 and R 6 each independently represent a hydrogen atom or the like, R 7 represents a monovalent substituent, R 8 represents a halogen atom or the like, and p represents an integer of 0 to 4, R 1 and R 2 each independently represent an alkyl group having 3 or more carbon atoms, or the like, and X 1 to X 3 each independently represent a hydrogen atom or the like. The colorant compound represented by General Formula (1) has a counter anion inside and/or outside the molecule.
• US7141657B2
  申请人：——

  公开号：US7141657B2

  公开（公告）日：2006-11-28
• US9671687B2
  申请人：——

  公开号：US9671687B2

  公开（公告）日：2017-06-06